- Modern approaches to the correction of vaginal dysbiosis in pregnant women after antibiotic therapy
Modern approaches to the correction of vaginal dysbiosis in pregnant women after antibiotic therapy
HEALTH OF WOMAN. 2018.9(135):62–64; doi 10.15574/HW.2018.135.62
Kravchenko O. V.
HSSEE «Bukovinsky State Medical University», Chernivtsi
The objective: is to evaluate the effectiveness of the use of the Floric probiotic system for the restoration of vaginal microbiocenosis after antibiotic therapy during pregnancy.
Materials and methods. We examined 58 pregnant women, in the II and III trimester of gestation, who received antibacterial therapy for bacterial vaginosis, nonspecific vaginitis and cervicitis, trichomonas colpitis and vulvovaginal candidiasis. All pregnant women underwent a general clinical examination, bacterioscopic and bacteriological examination of vaginal secretions immediately after the end of antibiotic therapy, on the 7th and 14th day of observation. All patients received probiotic Florica, which was used vaginally by 1–2 suppositories for 10 days after antibacterial therapy.
Results. Bacterioscopic and bacteriological examination of vaginal contents showed that antibacterial therapy leads to excessive growth of conditionally pathogenic flora and depression of symbiotic microorganisms. Lactic acid bacteria in the dynamics of treatment with probiotic Floric were detected in the increasing titer in the majority of the examined. Recovery of vaginal flora after treatment was observed in 56 (96.5%) women. The level of vaginal pH decreased to normal values (pH <4.5) in almost all women included in the examination group (94.8%).
Conclusion. Antibacterial agents, regardless of group affiliation, negatively affect the state of vaginal microbiocenosis, contributing to the development of antibacterial vaginal dysbiosis. The use of the Floric probiotic system allows to bring to a qualitatively new effective level the prevention and treatment of dysbiotic disorders in pregnant women, which will certainly improve the perinatal outcomes and ensure the formation of the physiological microbiocenosis in the biotopes of the newborn.
Key words: pregnancy, antibiotic therapy, dysbiosis, probiotic Florica.
1. Bilko TM. (2016). Korektsiia mikroekolohii orhanizmu liudyny synbiotykamy ostannikh pokolin. Akusherstvo. Hinekolohiia. Henetyka 2;4(6):46–50.
2. Limanskaya A.Yu., Voloshyna T.V., Baider A.K., Davydova I.V. (2017). Restoring the balance of vaginal and intestinal biotopes in preconceptional period after antibiotic therapy. Perinatologiya i pediatriya. 1(69):33–38; doi 10.15574/PP.2017.69.33
3. Gromova OA, Torshin IYu, Garasko EA. (2010). Molekulyarnyie mehanizmy razrusheniya bakterialnyih plenok pri topicheskom primenenii askorbinovoy kisloty. Ginekologiya 12;6:12–18.
4. Zhabchenko IA, Shevel TG. (2012). Profilaktika perinatalnyih oslozhneniy pri disbioticheskih sostoyaniyah u beremennyih. Tavricheskiy mediko-biologicheskiy vestnik 15;2;2 (58):253–256.
5. Zhuk SI, Shlyahtina AA. (2018). Upravlenie biotopami zhenschinyi – novyie podhody. Zdorove zhenschiny 6(132):34–36.
6. Seythanova BT, Shapambaev NZ, Olzhaeva RR, Kalmenova PE. (2014). Mikrobiotsenoz vlagalischa i beremennyih zhenschin. Nauka i zdravoohranenie 1:70–71.
7. Yankovskiy DS. (2007). Uluchshenie reproduktivnogo zdorovya zhenschinyi putem optimizatsii mikroekologii pischevaritelnogo i urogenitalnogo trakta. Reproduktivnoe zdorove zhenschiny 3(32):148–154.
8. Cucchiara S. (2017, Mar 10). Baby microbiome management. I International Summit dedicated to the problems of microbiota.Paris:2.
9. Kovachev S. (2018). Deference factors of vaginal lactobacilli. Critical Reviews in Microbiology. 44(1):31–39. https://doi.org/10.1080/1040841X.2017.1306688; PMid:28418713
10. Prince AL et al. (2014). The microbiome, parturition, and timing of birth: more questions than answers. J.Reprod. Immunol. 104–105:12–19. https://doi.org/10.1016/j.jri.2014.03.006; PMid:24793619 PMCid:PMC4157949
11. Probiotics during and after antibiotics. Designer probiotics are capable of more than reducing AAD. Nutracos. (2010). Suppl. Prebiotis/Probiotis: 8–12.
12. Aline C Freitas, Bonnie Chaban, Alan Bockinf et al. (2017). The vaginal microbiome of pregnant women is less rich and diverse, with lower prevalence of Mollicutes, compared to non-pregnant women. Scientific Reports 7; Article number: 9212.