• Modern aspects of cervical insufficiency etiology and pathogenesis

Modern aspects of cervical insufficiency etiology and pathogenesis

HEALTH OF WOMAN. 2018.9(135):10–14; doi 10.15574/HW.2018.135.10

Benyuk V. O., Korniets N. G. , Oleshko V. F.
Bogomolets National Medical University, Kiev
SE «Lugansk State Medical University», Rubizhne

The article deals with modern approaches to the etiology and pathogenesis of miscarriage in extremely early preterm labor. After all, newborns from such births are characterized by deep morphological and functional immaturity and form indicators of perinatal morbidity and mortality.

The causes of miscarriage are varied and numerous. Cervical Insufficiency (CI) plays an important in the pathogenesis of premature birth, which is the result of the failure of the circular muscles of the internal orifice, isthmus and cervix.

The existing types of CI are anatomical, functional and congenital.

CI is a multifactorial complication of pregnancy. Genetic, hormonal, inflammatory-infectious, immunological, traumatic factors play a role in its development. A special role among the risk factors is played by Undifferentiated Connective Tissue Dysplasia, which is the result of violations of its development with defects of the main substance and fibers. The mechanisms of etiology and pathogenesis of asymptomatic cervical opening in preterm pregnancy are considered by analyzing the changes of hormonal and nutritive homeostasis, the state of collagen metabolism in Undifferentiated Connective Tissue Dysplasia.

Key words: cervical insufficiency, extremely early premature birth, undifferentiated connective tissue dysplasia, hormonal imbalance, collagen metabolism disorder, nutritive disorders

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