- Medical advantages of controlled ovarian stimulation in poor responders patients with corifolitropin-alpha and antagonists of gonadotropine-rilising-hormon s in ART clinic
Medical advantages of controlled ovarian stimulation in poor responders patients with corifolitropin-alpha and antagonists of gonadotropine-rilising-hormon s in ART clinic
HEALTH OF WOMAN. 2018.3(129):39–45; doi 10.15574/HW.2018.129.39
Medical Center «Rodynne dzherelo»
The objective: study of the effectiveness of coriophyllotropin alpha in controlled ovarian stimulation regimens with gonadotropin-rilising hormone antagonists in poor responders.
Materials and methods. The study of the effectiveness of the controlled ovarian stimulation regimen using long acting FSH in the protocol with GnRH antagonists was compared with the daily administration of recombinant FSH by the number of oocytes received, embryo digestion, pregnancy and implantation.
Results. It has been shown that ovarian stimulation with the use of coriophyllotropin alfa is as effective as a daily injection of recombinant FSH for the treatment of patients with a poor response to stimulation. In addition, the perception of patients with protocols with corifolithopropin alfa results in better tolerability than traditional protocols due to fewer injections, which reduces the likelihood of early termination of treatment.
Conclusion. The presented results of the study prove the effectiveness of using corifolotropin alpha in combination with additional FSH daly doses and gonadotropin-rilising hormone antagonists. The effectiveness of this regimen is comparable with standard daily FSH injections for poor responders patients. The study regimen simplify the design of the stimulation scheme, minimize the number of injections, and shorten the duration of the cycle.
Key words: controlled ovarian stimulation, poor responders, coriophyllotropin alpha.
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