• Management of pregnancy and delivery in patients with epilepsy 
To content

Management of pregnancy and delivery in patients with epilepsy 

HEALTH OF WOMAN. 2015.6(102):41–44 

Management of pregnancy and delivery in patients with epilepsy 

Makarenko M.V, Govseev D.A, Denysenko N.M, Popel O.K, Sysa O.N., Timofeeva O.N.

Kyiv maternity hospital № 5 

Management of pregnancy and delivery in patients with epilepsy is very difficult process, wich requires both obstetntion and other expert. In article are given data of preconceptual, gestational period, delivery. Also presented information about AEDs, their metabolism, that allows healthcare professionals to make treatment decisions and to reduce the maternal and child risk. 

Ключевые слова: epilepsy, pregnancy, anti-epilepticdrugs. 


1. Адамян ЛВ, Карлов ВА, Жидкова ИА, Брагинская СГ, Златорунская МА, Кунькина ЮБ, Иванов АЕ. 2009. Особенности ведения беременности и родов у женщин, страдающих эпилепсией. Проблемы репродукции. Спец. выпуск. Материалы III Международного Конгресса по репродуктивной медицине:54.

2. Власов ПН. 2011. Беременность при эпилепсии, проблемы и перспективы. Эпилепсия и пароксизмальные состояния 3;4:45–46.

3. Демина ТН, Алипова НФ. 2009. Ведение беременности и родов у женщин с эпилепсией. Новости медицины и фармации:296.

4. Златорунская МА. 2014. Оптимизация ведения беременности, родов и послеродового периода у женщин с эпилепсией: Дис. канд. мед. наук.

5. Battino D, Tomson T, Bonizzoni E et al. 2013. Seizure control and treatment changes in pregnancy: observations from the EURAP epilepsy pregnancy registry. Epilepsia 54(9): 1621–1627. http://dx.doi.org/10.1111/epi.12302; PMid:23848605

6. Fried S, Kozer E, Nulman I, Einarson TR, Koren G. 2004. Malformation rates in children of women with untreated epilepsy: a meta-analysis. Drug Saf. 27(3):197–202. http://dx.doi.org/10.2165/00002018-200427030-00004; PMid:14756581

7. Harden CL, Pennell PB, Koppel BS et al. 2009. Practice parameter update: management issues for women with epilepsy – focus on pregnancy (an evidencebased review): vitamin K, folic acid, blood levels, and breastfeeding: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society. Neurology 73(2):142–149. Rigorous evidencebased review. http://dx.doi.org/10.1212/WNL.0b013e3181a6b312http://dx.doi.org/10.1212/WNL.0b013e3181a6b2f8http://dx.doi.org/10.1212/WNL.0b013e3181a6b325; PMid:19398680 PMCid:PMC3475193

8. Johannessen Landmark C, Johannessen SI, Tomson T. 2012. Host factors affecting antiepileptic drug deliverypharmacokinetic variability. Adv. Drug Deliv. Rev. 64(10):896–910. http://dx.doi.org/10.1016/j.addr.2011.10.003; PMid:22063021