• Levothyroxine substitution therapy in reproductive health and improving the quality of life of women of reproductive age with subclinical hypothyroidism
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Levothyroxine substitution therapy in reproductive health and improving the quality of life of women of reproductive age with subclinical hypothyroidism

HEALTH OF WOMAN. 2017.10(126):39–42; doi 10.15574/HW.2017.126.39

Varchenko L. M.
Kyiv City Clinical Endocrinology Center   

The objective: assessment of the dynamics of clinical manifestations of reproductive health (RH) and quality of life (QOL) under conditions of comorbidity in women of reproductive age with subclinical hypothyroidism (CGT) under the influence of replacement therapy with levothyroxine.
Materials and methods. The results of substitution treatment with levothyroxine drugs in 80 women of reproductive age with CGT are analyzed. The QL assessment was performed using a general MOS SF-36 questionnaire [7, 19] using the Evidence method.
Results. Substitution therapy with levothyroxine for 6 months was performed in 80 women of reproductive age with subclinical hypothyroidism; 47 women (58.8%) achieved complete eliminations of reproductive health disorders, general-somatic diseases, neuropsychological changes, elimination of comorbidity and improvement of quality of life in the MOS SF-36 questionnaire from medium to high. At the same time, in 33 women (41.2%), eliminations of reproductive health and comorbid manifestations in the non-genital area have survived. However, in these women, life quality indicators improved from medium to elevated values, however, they were leaner than in women without diseases.
Conclusions. The obtained data allow us to recommend the definition of quality of life indicators using the MOS SF-36 questionnaire as an integral criterion for evaluating the effectiveness of treatment in comorbid conditions in women of reproductive age with subclinical hypothyroidism.
Key words: subclinical hypothyroidism, substitution therapy, levothyroxine, comorbid conditions, quality of life, integral indicators of treatment efficacy.

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