• Interluekin 6 and integrated index of anamnesis, initial health status and gestation course as predictors of preterm delivery in women with multiple gestation
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Interluekin 6 and integrated index of anamnesis, initial health status and gestation course as predictors of preterm delivery in women with multiple gestation

PERINATOLOGY AND PEDIATRIC. UKRAINE. 2018.1(73):41-47; doi 10.15574/PP.2018.73.41

Bulavenko O. V., Vozniuk А. V., Tytarenko N. V., Kukuruza I. L.
National Pirogov Memorial Medical University, Vinnytsia, Ukraine

Objective — to identify diagnostic value of interleukin 6 and an integrated index of the anamnesis, initial health status and gestation course as predictors of preterm delivery in women with multiple gestation.
Material and methods. The analysis of anamnesis, initial health status, course of gestation and other characteristics of 78 women with multiple gestation was performed. Out of those women, in 25 pregnants there was preterm delivery before 34 weeks of gestation and in 53 cases — after 34 weeks. To predict the preterm delivery, a modified predicting model of the preterm delivery risk in women with multiple gestation as well as the interleukin 6 level in cervical mucus were used.
Results. Using ROC-analysis the threshold values were calculated, which were as follows: for the proposed integrated index of the anamnesis, initial health status and gestation course, it made up >-2.14 points (sensitivity — 64%, specificity — 81.1%), and the threshold value for cervical interleukin 6 was >41.65 pg/mL (sensitivity — 84%, specificity — 71.1%).
Conclusions. The comprehensive evaluation of the proposed integrated index of anamnesis, initial health status, gestation course and interleukin 6 concentration in cervical mucus allows predicting with high sensitivity and specificity preterm delivery in women with multiple gestation. The overall determination of the index with >-2.14 points and interleukin 6 concentration in cervical mucus of >41.65 pg/mL predicts preterm delivery in women with multiple gestation with negative predictive value of 90.4% and sensitivity of 80%.
Key words: multiple gestation, preterm delivery, interleukin 6, model of logistic regression.

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