• Influence of Resistol® Drug on Humoral and Cellular Immunity of Children with Recurrent and Acute Viral Respiratory Diseases: Research Findings
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Influence of Resistol® Drug on Humoral and Cellular Immunity of Children with Recurrent and Acute Viral Respiratory Diseases: Research Findings

SOVREMENNAYA PEDIATRIYA.2018.8(96):104-112; doi 10.15574/SP.2018.96.104

L.V. Kvashnina, V.P. Chernyshov, I.M. Matvienko, T.B. Ignatova, D.V. Osypchuk
State Institution «Institute of Pediatrics, Obstetrics and Gynecology named after Academician O.M. Lukyanova, National Academy of Medical Sciences of Ukraine», Kyiv

NK-lymphocytes (natural killers) are the main innate immunity effectors in overcoming viral infections: they participate in the immune defense, directly eliminate virus-infected and malignantly transformed cells, activate other cells of the immune system through the secretion of cytokines. Stimulation of TLRs, and TLR3 in particular, which are expressed in almost all NK-lymphocytes, activates them, leading to secretion of cytokines, IFN-γ, and increased cellular lysis of virus-infected and tumor cells. That is, recognition of viruses through TLR3 helps NK cells play a crucial role in the first line of organism protection against viral infections. The results of the research on the influence of the medicinal product «Resistol®» on the immune defense activity in children with ARVI and recurrent upper respiratory tract infections demonstrated that on the background of «Resistol®» use the number of NK cells that could directly recognize viral pathogens increased (p<0.05). At the same time, in the group of children with acute respiratory viral infections, who did not use Rezistol®, there was no significant change in the percentage of activated NK cells in peripheral blood. In the group of children with acute respiratory infections who used Resistol®, significantly higher absolute values of leukocytes and lymphocytes were registered as compared with the group of children in whom Resistol® was not used (p <0.05), whereas at the beginning of treatment and observation these data did not differ statistically between the groups (p> 0.05).

Key words: children, humoral immunity, cellular immunity, acute respiratory viral infection, recurrent infections, Pelargonium Sidoides, Resistol®.

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Article received: Aug 12, 2018. Accepted for publication: Dec 10, 2018.