• Influence of preparation of recombinant human interferon on the frequency of obstetric and perinatal pathology in pregnant women with infection of urinary tract 
To content

Influence of preparation of recombinant human interferon on the frequency of obstetric and perinatal pathology in pregnant women with infection of urinary tract 

HEALTH OF WOMAN.2015.7(103):116–120; doi 10.15574/HW.2015.103.116 
 

Influence of preparation of recombinant human interferon on the frequency of obstetric and perinatal pathology in pregnant women with infection of urinary tract 
 

Sergiyenko S. N., Ishchenko O. L., Shkola L. I.

SI «Lugansk state medical University» 
 

The problem of infection of urinary tract at pregnant women does not lose the urgency now. The inefficiency of treatment of this pathology is connected with physiological decrease in immunity at such patients. Additional using of recombinant human interferon in the form of a preparation genferon for treatment of pregnant women with pyelonephritis is offered.

120 patients with gestational pyelonephritis or exacerbation of chronic pyelonephritis which have developed at them in term of pregnancy of 13-17 weeks have been surveyed. The 1-st group was formed by 70 persons who received the standard treatment, the 2-nd group was generated by 50 women who in addition received genferon.

After the suffering for infectious diseases of kidneys during pregnancy, its further course is characterized by increase of frequency of threated abortion and premature deliveries, gestosis and placentary dysfunction; during labors a premature rupture of amniotic membranes and distress of fetus was more widespread. At such patients the placenta in many cases had both ultrasonic, and histological attributes of infection. Occurrence during the pregnancy of inflammatory diseases of kidneys was accompanied by significant distribution of the pathology connected with intra-uterine infection among newborns.

Additional application of a preparation genferon for treatment of pyelonephritis during the second trimester of pregnancy in comparison with the standard treatment leads to authentic decrease in frequency both obstetrical complications and perinatal pathology. 
 

Key words: infection of urinary tract, complications of pregnancy, intra-uterine infection, pathology of newborns. 
 

REFERENCES

1. Архипова НА, Грицай ІМ, Данилків ОО. 2009. Аналіз перебігу вагітності, перинатальних утрат і стану надання спеціалізованої медичної допомоги вагітним із захворюваннями нирок. Здоровье женщины 3(39):55–58.

2. Краснопольский ВП, Тареева ТГ, Малиновская ВВ. 2004. Система иммунокоррекции при хронических инфекционно-воспалительных заболеваниях у беременных. Российский вестник акушера-гинеколога 1:36–38.

3. Меленчук ЛМ. 2011. Пренатальна оцінка стану плода у вагітних жінок з іфекційними захворюваннями сечовидільної системи: Автореф. дис. канд. мед. наук. Львів:18.

4. Никонов АП, Асцатурова ОР. 2004. Инфекции в акушерстве и гинекологии. Практическое руководство по диагностике и антимикробной химиотерапии. Методические рекомендации. Инфекции и антимикробная терапия 6;3:65–72.

5. Сидорова ИС. 2010. Прогнозирование исходов беременности и родов при остром гестационном пиелонефрите. Акушерство и гинекология 4:37–40.

6. Сухих ГТ, Ванько ЛВ. 2003. Иммунология беременности. М, Медицина:420.

7. Туманова ЛЄ, Рахубінська ВВ, Данков ОВ. 1998. Фактори, які сприяють виникненню акушерської та перинатальної патології у жінок з хронічним пієлонефритом. Педіатрія, акушерство і гінекологія 1:66–68.

8. Уджуху ВЮ, Петрунин ДД, Кубылинский АА. 2005. Суппозитории Генферон – высокоэффективный компонент комплексной терапии урогенитальных инфекций. Проблемы репродукции 4:42–48.

9. Цинзерлинг ВА, Мельникова ВФ. 2002. Перинатальные инфекции. Вопросы патогенеза, морфологической диагностики и клинико-морфологических сопоставлений. Практическое руководство. СПб, Медицина:352.

10. Юнкеров ВИ. 2002. Математико-статистическая обработка данных медицинских исследований. СПб, Изд-во ВМедА:266.