• Influence of iron deficiency anemia on the formation of systemic immunity in children.
To content

Influence of iron deficiency anemia on the formation of systemic immunity in children.

SOVREMENNAYA PEDIATRIYA.2014.3(59):40-43; doi 10.15574/SP.2014.59.40

 

Influence of iron deficiency anemia on the formation of systemic immunity in children.

 

Banadyha N. V., Rogalska Ya. V., Rogalsky I. O.

SHEI «Ternopil State Medical University by I.Ya.Horbachevsky, Ministry of Health of Ukraine», Ternopil, Ukraine

 

Purpose: to evaluate the functional status of the immune system in children of various age with diagnosed iron deficiency anemia.

 

Patients and methods. The study involved 106 children under the age of 3 years with diagnosed iron deficiency anemia (IDA). Were analyzed thoroughly factors of development of sideropenic conditions and probable immunodeficient disease. Activity of systemic immune response development in children with anemia was monitored by indexes of cellular (T-, B-lymphocytes) and humoral immunity (Ig A, M, G). 

 

Results. In young children with IDA was founded significant reduction in the total number of T-lymphocytes (CD3+), CD22+, CD16+, CD4+ and CD8+, compared with values of the control group, both as in the case of presence of an infectious inflammatory disease, and in the case of its absence. Also was diagnosed decreasing of absolute and relative amount of T- lymphocytes and their subpopulations, and that indicated to some extent of reduction of both helper and suppressor activity of cellular immunity. Analyzis of immunoglobulins values in the serum of patients with IDA without any concomitant acute infectious disease showed specific dysimmunoglobulinaemia, which was associated with significantly low levels of IgG, IgA, and normal values of Ig M. However, in the case of IDA, combined with acute respiratory disease, was tracked significant increasing in Ig A and Ig M values, with decreased level of IgG. Significant difference between level of immunoglobulin A (p <0.05) and M with the same indexes of the group of children without any acute disease indicates for the activation of the humoral response while presence of infectious pathology. 

 

Conclusions. In young children with IDA was founded significant reduction in the total number of T- lymphocytes and their subpopulations, and that indicated reduction of both helper and suppressor immunity activity, and can serve as proof of the violation in rates of physiological maturation and differentiation of the immune response. The last one is indicated by significant deficit of Ig G in children with IDA, which shows late immune start in patients with anemia, regardless of existing of some infectious disease or without it. 

 

Key words: iron deficient anemia, infants, toddlers, immunity, children.

 

REFERENCES

1. Банадига НВ. 2013. Сутність диселементозу у дітей із залізодефіцитною анемією. Совр педиатрия. 6: 105—108.

2. Бут Г. 2008. Микроэлементы и их роль в в обеспечении иммунного ответа. Нов медицины и фармации. 4: 13.

3. Вильмс ЕА, Турчанинов ЛВ, Турчанинова МС. 2011. Микроэлементозы у детского населения мегаполиса: эпидемиологическая характеристика и возможности профилактики. Педиатрия. Журнал им. Г. Н. Сперанского. 1(90): 96—101.

4. Горячковский АМ. 2005. Клиническая биохимия в лабораторной диагностике. Экология: 616.

5. Копина МН. 2000. Многофакторный анализ причин развития железодефицитных состояний и изменения клеточного и гуморального иммунитета у больных железодефицитной анемией. Вестн Новгородского гос. ун-та. 14: 34—38.

6. Марушко ЮВ. 2013. Мікроелементи та стан імунітету в дітей. Актуальна інфектол. 1.

7. Нетребенко ОК, Щеплягина ЛА. 2006. Иммунонутриенты в питании детей. Трудный пациент. 4;6: 21—26.

8. Реброва ОЮ. 2002. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA. М, Медиа Сфера: 312.

9. Тарасова ИС, Чернов ВМ. 2012. Новые направления в диагностике, лечении и профилактике железодефицитных состояний. Совр педиатрия. 2(42): 18—24.

9(1). Тотолян АА, Балдуева ИА, Бубнова ЛИ. 1999. Стандартизация методов иммунофенотипирования клеток крови и костного мозга человека. Мед иммунол. 1;5: 21—43.

10. Andrews NC. 2002. Iron metabolism and related disorders. Geneva, ChavanesdeBogis: 1—5.

11. Ibs KH, Rink L. 2003. Zinc Altered immune function. J Nutr. 133: 1452—1456.

12. Mancini G, Tahey I, Mekelvey E. J 1965. Immunology. 74: 84—102.

13. Ponka P. 2006. Iron metabolism:Physiology and pathophisiology. J Trace Elem Exp Med. 13(1): 73—83. http://dx.doi.org/10.1002/(SICI)1520-670X(2000)13:1<73::AID-JTRA9>3.0.CO;2-X