• The influence of the functional state of the pituitary-thyroid system in the neuropsychological development of young children
en To content Full text of article

The influence of the functional state of the pituitary-thyroid system in the neuropsychological development of young children

Modern Pediatrics.Ukraine.2020.3(107):23-28; doi 10.15574/SP.2020.107.23
Mamenko M. E.1, Shlieienkova H. O.2
1Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine
2V.N. Karazin Kharkiv National University, Ukraine

For citation: Mamenko ME, Shlieienkova HO. (2020). The influence of the functional state of the pituitarythyroid system in the neuropsychological development of young children. Modern Pediatrics. Ukraine. 3(107): 2328; doi 10.15574/SP.2020.107.23
Article received: Jan 01, 2020. Accepted for publication: Apr 11, 2020.

Insufficient thyroid hormones (THs) in the early childhood can lead to severe impairments in the development of the central nervous system because THs are critical to central nervous system development.
Materials and methods. Target group: 123 children from orphanage. The study was carried out after obtaining the opinion of the ethics commission, the consent of local authorities and guardians. Methods: psychomotor development accession; thyroid status by TSH, TT4, TT3 serum-based measuring (IMA)
Results. One third of surveyed children proved to have minimal thyroid dysfunction (TSH levels over 4.0 mU/L in 27.1±4.1% of cases). The maximum TSH level was 8.6 mU/L. The level of T4 and T3 during the survey was within the reference values. In young children with a severe state of pituitary-thyroid system function, clinical symptoms of nervous system damage were observed significantly more often than in children with an optimal function state. Negative linear correlation by PPMCC between TSH levels and coefficients of neuro&psychological development was detected (ρ=-0.436, p<0.001).
Conclusions. Minimal thyroid dysfunction was detected in 27.1±4.1% children. Reduced activity of the pituitarythyroid axis has a negative impact on the neuropsychological development of the child, reflecting the negative correlation (ρ=-0.436, p<0.001)) between TSH and ratio of mental development.
No conflict of interest was declared by the authors.
Key words: neuropsychological development, pituitary-thyroid system, young children.

REFERENCES

1. Kozlovska HV. (2007) «HNOM». Metodychnyi posibnyk. Moskva: 152

2. Martyniuk VIu. (2001). Klasyfikatsiia urazhen nervovoi systemy u ditei ta pidlitkiv: metodychnyi posibnyk. Kyiv: Feniks: 190.

3. MOZ Ukrainy. (2008). Klinichnyi protokol medychnoho dohliadu za zdorovoiu dytynoiu vikom do 3 rokiv. Nakaz MOZ Ukrainy vid 31.03.2008 No.149. Kyiv: 45.

4. Biondi B, Cooper DS. (2008). The clinical significance of subclinical thyroid dysfunction. Endocr Rev.29: 76—131. https://doi.org/10.1210/er.2006-0043; PMid:17991805

5. Ergur AT, Taner Y, Ata E, Melek E et al. (2012). Neurocognitive functions in children and adolescents with subclinical hypothyroidism. J Clin Res Pediatr Endocrinol.4: 21—24. https://doi.org/10.4274/Jcrpe.497; PMid:22394701 PMCid:PMC3316458

6. Henrichs J, Bongers0Schokking JJ, Schenk JJ, Ghassabian A et al. (2010). Maternal thyroid function during early pregnancy and cognitive functioning in early childhood: the generation R study. J Clin Endocrinol Metab.95: 4227—4234.

7. Jonklaas J, Bianco AC, Bauer AJ, Burman KD et al. (2014, Dec). Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement. Thyroid. 24(12): 1670—751. https://doi.org/10.1089/thy.2014.0028; PMid:25266247 PMCid:PMC4267409

8. Julvez J, Alvarez0Pedrerol M, Rebagliato M, Murcia M et al. (2013). Thyroxine levels during pregnancy in healthy women and early child neurodevelopment. Epidemiology.24: 150—157. https://doi.org/10.1097/EDE.0b013e318276ccd3; PMid:23232616

9. Leger J, Olivieri A, Donaldson M, Torresani T et al. (2014, Feb). European Society for Paediatric Endocrinology consensus guidelines on screening, diagnosis, and management of congenital hypothyroidism. J Clin Endocrinol Metab. 99(2): 363—84. https://doi.org/10.1210/jc.2013-1891; PMid:24446653 PMCid:PMC4207909

10. Li Y, Shan Z, Teng W, Yu X et al. (2010). Abnormalities of maternal thyroid function during pregnancy affect neuropsychological development of their children at 25—30 months. Clin Endocrinol (Oxf). 72: 825—829. https://doi.org/10.1111/j.1365-2265.2009.03743.x; PMid:19878506

11. Rapa A, Monzani A, Moia S, Vivenza D et al. (2009). Subclinical hypothyroidism in children and adolescents: a wide range of clinical, biochemical, and genetic factors involved. J Clin Endocrinol Metab.94: 2414—2420. https://doi.org/10.1210/jc.2009-0375; PMid:19417038

12. Su PY, Huang K, Hao JH, Xu YQ et al. (2011). Maternal thyroid function in the first twenty weeks of pregnancy and subsequent fetal and infant development: a prospective population-based cohort study in China. J Clin Endocrinol Metab.96: 3234—3241. https://doi.org/10.1210/jc.2011-0274; PMid:21832110

13. Zacharin M. (Editor). (2011). Practical Paediatric Endocrinology in a Limited Resource Setting. Melburne, Australia: 320.