• Influence of feeding on the severity of necrotizing enterocolitis in preterm infants

Influence of feeding on the severity of necrotizing enterocolitis in preterm infants

SOVREMENNAYA PEDIATRIYA.2018.3(91):33-37; doi 10.15574/SP.2018.91.33

Rusak N. P.
National Pirogov Memorial Medical University, Vinnytsia, Ukraine

Objective: to study the influence of the feeding pattern of premature infants with necrotic enterocolitis (NEC) of varying severity on the further course of the disease.

Material and methods. In total 67 premature infants were under observation, who were divided into 3 groups: group I consisted of 20 children with NEC I stage, group II — 30 children with NEC II stage, group III — 7 children with NEC III stage. The control group comprised 10 preterm infants without NEC. Statistical processing of the results was carried out using the software package Statistica 6.1. The difference in parameters was considered statistically significant with p<0.05.

Results. The children of groups III and II started enteral nutrition later — at the age of 3.6±0.7 and 2.9±0.4 days of life, than the children of group ІІ — on 1.4±0.1 day of life and the children from the control group — at the age of 1.2±0.1 day (р<0.01). In early neonatal period, there were breastfed 4.2 times less children of group ІІІ, than of the control group — 1 (14.3%) and 6 (60.0%) children, respectively (p<0.05). The children from group III were longer on an enteral nutrition through an orogastric probe compared to children of other groups — 59.1±4.9 days (p<0.01). After the first clinical symptoms onset of NEC, the duration of total parenteral nutrition was significantly higher in the children of group III — 9.9±1.9 days (р<0.01). After restoring tolerance to enteral nutrition, the children from the main groups were restarted the enteral feeding and administered partial parenteral nutrition. The duration of partial parenteral nutrition in the children of group I was significantly shorter than those of group II — 26.8±3.9 and 34.8±4.8 days, respectively (р<0.05), and the children of group III — 52.9±4.3 days (р<0.01).

Conclusions. The severe course of NEC is associated with later initiated enteral nutrition — at the age of 3.6±0.7 days (р<0.01), the lack of breastfeeding in 6 (85.7%) children (р<0.05) and, as a consequence, a long stay on enteral feeding through the orogastric probe — 59.1±4.9 days, the prolongation of the total parenteral nutrition — 9.9±1.9 days and partial parenteral nutrition — 52.9±4.3 days (р<0.01).

Key words: necrotic enterocolitis, premature infants, feeding.


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