• The importance of adrenergic blockers to treat children with neuromuscular dysfunction of the bladder
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The importance of adrenergic blockers to treat children with neuromuscular dysfunction of the bladder

Paediatric surgery.Ukraine.2019.3(64):17-21; doi 10.15574/PS.2019.64.17

D.V. Shevchuk
Zhytomyr Oblast Children’s Clinical Hospital, Stanishevka, Ukraine
Zhytomyr Ivan Franko State University, Ukraine
Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine

For citation: Shevchuk DV. (2019). The importance of adrenergic blockers to treat children with neuromuscular dysfunction of the bladder. Paediatric Surgery. Ukraine. 3(64): 17-21. doi 10.15574/PS.2019.64.17
Article received: May 27, 2019. Accepted for publication: Sep 12, 2019.

Selective alpha-blockers are widely used in urological practice for the treatment of benign prostatic hyperplasia and lower urinary tract symptoms. Safety and efficacy of selective α-blockers in children with neuromuscular dysfunction of bladder noted a number of foreign authors. However, experience with α-blockers for the treatment of dysfunctions of the urinary bladder in children in Ukraine poor.
The aim of the study. To study the safety and efficacy of selective α1-blocker in the treatment of neuromuscular dysfunction of the bladder in children of all ages.
Materials and methods. The safety and efficacy of selective α-blocker doxazosin at a dose of 0.25-1.0 mg/day in the treatment of neuromuscular dysfunction of the bladder in 90 children who were treated in a surgical department No.2 Zhytomyr Oblast Children’s Clinical Hospital were learnt. The age of patients ranged from 1 month to 17 years (mean 4.8 years). The boys were 74 (82.2%), 16 girls (17.8%).
Results. The duration of the drug ranged from 6 months to 3 years. Equipment inspection subject 40 (44.4%) children. In 36 (90%) patients with neuromuscular dysfunction of the bladder were recorded changes in subjective feelings. The noted speaker in urodynamic and ultrasound parameters, indicating improvement Cumulative-evacuation function of the bladder. On the control cystoscopy detected trabekulyarnosti and reducing the number psevdodyvertykuliv.
Conclusions. Thus, the use of selective α-blockers (doxazosin) is safe and quite effective in treatment of neuromuscular dysfunction of the bladder in children. However, without surgical correction causes neuromuscular dysfunction of the bladder, pharmaceuticals monotherapy is inadequate.
The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee (LEC) of all participating institution. The informed consent of the patient was obtained for conducting the studies.
No conflict of interest was declared by the author.
Key words: children, treatment, bladder, neuromuscular dysfunction of the bladder, α-blockers.

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