- Immunity changes in patients with gynaecological, surgical and simultaneous pathology in pre- and postoperative periods
Immunity changes in patients with gynaecological, surgical and simultaneous pathology in pre- and postoperative periods
PERINATOLOGY AND PEDIATRIC. UKRAINE. 2018.2(74):36-40; doi 10.15574/PP.2018.74.36
Dronova V. L., Dronov O. I., Teslyuk R. S.
SI «Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine», Kyiv
Bogomolets National Medical University, Kyiv, Ukraine
Objective: to study the features of changes of the immune status of patients with gynaecological, surgical and simultaneous pathology in the pre- and postoperative periods for injury evaluation of surgical interventions.
Material and methods. The study involved 97 patients who provided surgical service in the Department of Operative Gynaecology of SI «Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine». They were divided into two groups: group I comprised 70 patients with isolated gynaecological pathology, in group II included 27 women with simultaneous pathology. In the study 26 patients (group III) were also enrolled with isolated surgical pathology, who were provided a surgical care in the Surgical Department of Municipal Clinical Hospital No. 10 in Kyiv. The study was conducted within 10 months of 2017. The parameters of immune homeostasis in the pre- and postoperative periods were studied in 27 women with simultaneous operations, in 31 women operated for gynecological pathology, and in 26 women – for surgical pathology. Interleukin-6 was determined using Access 2 Beckman Counter's immune analyser, and C-reactive protein was measured with the Beckman Counter AU 480 immune analyser.
Results. It was established that irrespective of the increasing extent of operation for simultaneous pathology as compared with isolated surgical interventions for gynaecological and surgical pathology, the degree of tissue injury or operational trauma is relatively the same, confirming the gradual reduction the concentration of interleukin-6 to almost reference values.
Conclusions. The most informative indicator of the severity of surgical aggression is interleukin-6. It proportionally reflects the degree and dynamics of operational trauma. In turn, C-reactive protein indirectly reacts to injury and can be used as an additional indicator in monitoring in the postoperative period.
Key words: immunity status, pre- and postoperative periods, simultaneous, gynaecological and surgical pathology, operational trauma.
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