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Human Virome

SOVREMENNAYA PEDIATRIYA.2019.1(97):49-74; doi 10.15574/SP.2019.97.49

Yankovsky D. S., Dyment G. S., Berezhnoy V. V., Kitam V. O., Khimich N. V.
Science production company «O.D. Prolisok», Kyiv, Ukraine

The review is dealt with virome, a viral component of human microbiome. Modern data are discussed that concern the structure of virome, its formation during ontogenesis, the role in disease pathogeneses and in homeostasis maintenance. Special attention is payed to bacteriophages (phagobiome) as dominant members of virome. Modern data are submitted about the influence of bacteriophages on the state of microbiome prokaryotic community, immune system and their potential participation in the development of pathologies. Controversial questions, connected with the perspective of using bacteriophage therapy in medicine, are considered.

Key words: virome, microbiome, viruses, bacteriophages, metagenomics, prokaryotes, phagobiome, phage therapy.


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Article received: Nov 03, 2018. Accepted for publication: Feb 08, 2019.