• Hormonal profile in pregnant women with chronic gastritis accompanied with early gestation complications

Hormonal profile in pregnant women with chronic gastritis accompanied with early gestation complications

HEALTH OF WOMAN. 2018.10(136):44–47; doi 10.15574/HW.2018.136.44

Zherebak N. М., Gnatko O. P.
Bogomolets National Medical University, Kiev

The objective: To determine the hormonal profile (progesterone, estradiol, chorionic gonadotropin hCG) in pregnant women with chronic gastritis accompanied with early gestational complications (emesis gravidarum, threatened miscarriage).

Materials and methods. 120 pregnant women of reproductive age with early gestational complications (emesis gravidarum, threaten miscarriage, spontaneous abortion) were examined. They were divided into two groups: Group 1 included 58 (48.3%) patients with chronic gastritis and Group 2 included 62 (51.7%) pregnant women without gastritis at 8–14 weeks of gestation. In addition to the standard clinical and laboratory examination of patients, the levels of progesterone, estradiol and chorionic gonadotropin in the blood serum were determined by the ELISA method. Statistical analysis of the results was performed using MedStat package (Lyakh Yu.Ye., Guryanov V.G., 2004–2017). In order to represent the quantitative characteristics in the figures, the median value of the parameter, the values of the first and third quartiles were given, the mean value and its 95% confidence interval (95% CI) were also indicated, and Mann-Whitney test was used to compare between the groups. The critical level of significance is 0,05.

Results. The largest percentage (34.4%) of the examined patients of Group 1 were older women (31–35 years). Pregnant women of active reproductive age (26–30 years) were more common among women of Group 2. 19 (32.8%) patients of Group 1 and 26 (41.9%) patients of Group 2 had various menstrual disorders. The most common disorders included Hyperemesis gravidarum (29% in groups 1 and 2) and threatened miscarriage (60.3% in Group 1, 51.6% in Group 2). In the group of pregnant women with gastritis, the average level of estradiol was 304.1 (190.6–488.9) pg/ml and was lower than in women of Group 2, where the average level of this hormone was 424.8 (231.6–1081.9) pg/ml, respectively. The average level of progesterone in pregnant women with gastritis was 15.4 (5.6–29.4) pg/ml and was lower than in patients without gastritis 20,6 (8,9–39,8) pg/ml. In pregnant women with gastritis, the average level of hCG was 4637.9 (1732–19600) mIU/ml, and 16611.7 (3500.2–19 600) mIU/ml in pregnant women without gastritis, respectively. Although in pregnant women of Group 1, the average levels of this parameter were higher than in patients of Group 2, no significant difference was found.

Conclusion. The data obtained suggest that in pregnant women with chronic gastritis, the hormonal profile is characterized by significant changes in estradiol, which plays a certain role in the development of early gestational complications.

Key words: pregnancy, chronic gastritis, estradiol, progesterone, chorionic gonadotropin, gestational complications.

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