- Hormonal function of mother–placenta–foetus system of pregnant women with psycho-emotional disorders stipulated by anxiety
Hormonal function of mother–placenta–foetus system of pregnant women with psycho-emotional disorders stipulated by anxiety
PERINATOLOGY AND PEDIATRIC. UKRAINE. 2018.1(73):57-60; doi 10.15574/PP.2018.73.57
Syusyuka V. G.
Zaporizhzhya State Medical University, Zaporizhzhia, Ukraine
Objective – to assess the hormonal function of mother–placenta–foetus system of pregnant women with psycho–emotional disorders stipulated by anxiety.
Material and methods. There were examined 86 women in the II trimester and at the beginning of III trimester of pregnancy. The main group included 60 pregnant women with medium and high level of state anxiety and 26 pregnants with anxiety level of 30 points and lower that indicates the low level of state anxiety (comparison group). In order to evaluate the state anxiety and trait anxiety, the scale of Ch.D.Spielberger adapted by Yu.L.Hanin was used. Quantitative assessment of the hormones in blood plasma was determined by means of enzyme immunoassay on the «SIRIO S» apparatus. For determination of level of unconjugated oestriol (Oe3), progesterone (P) and placental lactogen (PL), DRG test systems (Germany) were used. Variational and statistical processing of the results was made with licensed standard package of application software program for multivariate statistical analysis STATISTICA 6.0 (license No. AXXR712D833214FAN5).
Results and conclusions. Research groups were divided depending on state anxiety level. It was found that the mean value of state anxiety in the comparison group made up 26.3±1.2 points and it was statistically and significantly lower (p<0.05) than the mean value of the main group (37.9±1.4 points). It is necessary to note that the trait anxiety level, which is stable individual feature reflected tendency of a person to anxiety, was also statistically and significantly lower (p<0.05) in the comparison group and made up 38.5±2.6 points against 43.4±1.2 points in the main group. For assessment of functional state of mother–placenta–foetus system hormonal function, the PL, Oe3 and P concentrations were determined. All of presented hormones had positive correlation with gestation term, namely: PL (r=+0.602, p<0.05), Oe3 (r=+0.484, p<0.05) and P (r=+0.572, p<0.05) No connection of examined hormones with anxiety level revealed. Such results were reflected in absence of statistically significant difference (p>0.05) between level of hormones of mother–placenta–foetus system depending on anxiety level. The data obtained suggest that across pregnancy the sufficient adaptive mechanisms, which can provide the required hormonal homeostasis in mother–placenta–foetus system, even in conditions of psycho–emotional state violation of pregnant women, are in evidence.
Key words: pregnancy, psycho-emotional status, anxiety, hormones, unconjugated oestriol, progesterone, placental lactogen.
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