• Herpesvirus infections in children with chronic glomerulonephritis 
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Herpesvirus infections in children with chronic glomerulonephritis 

 

SOVREMENNAYA PEDIATRIYA.2015.4(68):115-118; doi 10.15574/SP.2015.68.115 
 

Herpesvirus infections in children with chronic glomerulonephritis 
 

Kruglikova I. V., Fomina S. P., Bagdasarova I. V.

SI «Institute of Nephrology of NAMS of Ukraine», Kiev 
 

Objective. To study the Herpesviridae infection in children with glomerulonephritis and kidney pathology course, depending on the availability of co-infection. 
 

Patients and methods. A total of 110 children in the age from 2 to 17 years, the patients of the Nephrology department are observed. Complex survey, in addition with conventional methods (clinical, instrumental and laboratory), included the definition of infection with herpes simplex virus type 1/2, cytomegalovirus and Epstein-Barr virus. 
 

Results. In 77.2% of cases for glomerulonephritis was typical related herpes virus infection. Most commonly diagnosed infection with Epstein-Barr virus (60.9%), relatively often in monovariant (41.5%). Herpes simplex virus (types 1/2) and cytomegalovirus in the majority of cases was accompanied by a combined infection (93.6% and 82.9%, respectively). Clinical variants glomerulonephritis were differ by its structure of infections: patients with hematuric form was dominated infection by one type of virus (40.6%); during the nephrotic syndrome was marked combined lesion (56.6%), most often found cytomegalovirus infection (47.8%), mainly at presence of steroid resistance (54.5% vs. 41.7% at steroid sensibility). Associated infections affected on the outcome of glomerulonephritis, simulating unfavorable course and promoting conservation of disease activity during the hematuric form and steroid resistant nephrotic syndrome in 64.5% and 83.3%, respectively), early relapse steroid sensitive nephrotic syndrome (60.0%). 
 

Conclusions. The obtained data certifies about the need of preventive examinations of patients with glomerulonephritis for the aim of determination of their infection status and review of therapeutic support. 
 

Key words: children, glomerulonephritis, herpes virus infection. 
 

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