• Heat shock proteins in the diagnosis and prognosis of reproductive disorders in women

Heat shock proteins in the diagnosis and prognosis of reproductive disorders in women

HEALTH OF WOMAN. 2018.7(133):77–83; doi 10.15574/HW.2018.133.77

Yakovenko L. F., Romashchenko O. V., Kroupskaya I. V.                          
Institute of Molecular Biology and Genetics of the National Academy of Sciences of Ukraine, Kyiv
Institute of Urology, National Academy of Medical Sciences of Ukraine, Kyiv

Heat shock proteins are structurally highly conserved and abundantly expressed by prokaryotic and eukaryotic cells under stressful conditions. HSPs are immunodominant antigens for many microbes. They are overexpressed at sites of acute and chronic inflammation and involved in the patogenesis of various diseases.

Clinical studies and results of own investigations provided evidence that HSPs and anti-HSPs antibodies can be biomarkers for the diagnosis and prognosis of reproductive disorders in women. The involvement of HSPs and anti-HSPs antibodies in pathogenesis of tubal infertility, ovarian failure, pregnancy loss is discussed.

Key words: heat shock proteins, antibodies against heat shock proteins, infertility, pregnancy loss, in vitro fertilisation.


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