• Gestational dynamic of content and balance of essential trace elements in serum and erythrocytes of women of different reproductive age, giving birth for the first time
To content

Gestational dynamic of content and balance of essential trace elements in serum and erythrocytes of women of different reproductive age, giving birth for the first time

HEALTH OF WOMAN. 2016.10(116):49–52; doi 10.15574/HW.2016.116.49

Gestational dynamic of content and balance of essential trace elements in serum and erythrocytes of women of different reproductive age, giving birth for the first time

Markevich V. V.
National Medical Academy of Postgraduate Education P. L. Shupyk, Kiev

The objective: to study dynamics of software of serum and erythrocyte with essential microelements (iron, copper, zinc, cobalt, magnesium, manganese) during pregnancy in women of different reproductive age in a case of the first delivery.

Patients and methods. The definition of essential microelements conducted in serum and red blood cells in 44 pregnant women of early and middle reproductive age who gave birth for the first time. Pregnant women of reproductive age were respectively 16.33±0.21 and 24.67±0.37 years. The study was conducted in the first, second and third trimesters of pregnancy at 10.26±0.34, 23.23±0.51 and 36.08±0.59 weeks of gestation, respectively. For determination of microelemennts used spectrophotometry С – 115M1.

Results. For the course of pregnancy in women of middle reproductive age was typical considerable dynamism of serum and erythrocyte content of microelements. During pregnancy significantly improves the condition of serum iron pool. Serum level of other essential microelements to the end of pregnancy significantly decreased, especially magnesium – three times, cobalt and manganese – twice, zinc had a tendency to reduce. Reduction of essential trace elements (magnesium, cobalt, manganese, zinc) is due to their active use of fetus especially in the third trimester of pregnancy.
In women of early reproductive age for the end of the third trimester of pregnancy, we found depletion of serum and erythrocyte content of iron and manganese, which can contribute to anemia. Increasing in the cobalt content in both environments shows voltage in hematopoietic system.

Conclusion. With the aim to examine the features of microelement software of fetus and development of methods of its correction, it seems appropriate to study the content and balance of essential trace elements in the mother-placenta-fetus.

Key words: essential microelements, pregnant women, reproductive age, the first birth.


1. Zhuravskaya EY, Koutsenogii KP, Chankina OV et all. 2006. Trace elements and some parameters of human health. Bulletin SB RAMS 4(122):116-120.

2. Veropotvelyan PM, Veropotvelyan MP, Kapalina OM et al. 2012. Microelements and pregnancy. Pediatrics, Obstetrics and gynecology 2:95-100.

3. Veropotvelyan PN, Veropotvelyan NP, Pogulyay YS et al. 2014. The importance of microelementsnts during pregnancy. Health of woman 8(94):57-64.

4. Kravets OM, Kravets TP. 2008. The physiological importance of micronutrients for women of reproductive age. Health of woman 2(34):37-40.

5. Artemeva EK, Setko NP, Saprykin VB et al. 2004. The concentration of trace elements in the system mother-placenta-fetus in areas with different levels of anthropogenic load. Microelements in medicine 4:1-3.

6. Antonov AR, Efremov AV, Nefedova NG. Zinc concentration in serum during normal and pathological pregnancy. Questions of child nutrition in 2004. 2(6):10-12.

7. Rudenko IV. 2009. The role of macro-microelements in development of natural defects. Achievements of biology and medicine 1(13):94-99.

8. Ahadzhanyan NA, Veldanova MV, Skalniy AV. 2001. Ecological portrait of man:88.

9. Markevich VE, Tarasova IV, Turova LO et al. 2007. Trace element supply in the system mother-placenta-fetus-newborn. The series «Medicine» 1:52-58.

10. Mello-da-Silva CA, Fruchtengarten L. 2005. Environmetal chemical hazards and child health. J.Pediatr 81:205-211. https://doi.org/10.2223/JPED.1409; PMid:16355265

11. Wigle DT, Arbuckle TE, Walker M et al. 2007. Environmetal hazards: evidence for effects on child health. J.Toxicol. Environ. Health B. Crit. Rev. 10(1-2):3-39. https://doi.org/10.1080/10937400601034563; PMid:18074303

12. Children’s environment and health action plan for Europe. Ministerial document. WHO Regional Office for Europe. Copenhagen. 2004:1-8.

13. Sram RJ, Binkova B, Dejmek J, Bobak M. 2005. Ambient air pollution and pregnancy outcomes: a review of the literature. Environ Health Perspect. 113(4):375-382. https://doi.org/10.1289/ehp.6362; PMid:15811825 PMCid:PMC1278474

14. Axelrod D, Davis DL, Hajek RA. 2001. It’s time to rethink dose: the case for combining cancer, and birth and developmental defects. Environ Health Perspect. 109(2):246-249. https://doi.org/10.1289/ehp.109-a246

15. Perera FP, Yedrychowski W, Rauh V. 1999. Molecular epidemiologic research on the effect of environmental pollutants on the fetus. Environ Health Perspect. 107(4):451-460. https://doi.org/10.1289/ehp.99107s3451; PMid:10346993 PMCid:PMC1566212