• Geoendemic evaluation of clinical and epidemiological features of growth hormone deficiency in children of Odesa region based on the 15-year monitoring

Geoendemic evaluation of clinical and epidemiological features of growth hormone deficiency in children of Odesa region based on the 15-year monitoring

PERINATOLOGY AND PEDIATRIC. UKRAINE. 2017.3(71):81-86; doi 10.15574/PP.2017.71.81

Ariaiev M. L., Biriukov V. S., Senkovska L. I., Gudz V. A., Luchnikova T. V.
Odesa National Medical University, Odesa, Ukraine
Odesa Regional Children's Clinical Hospital, Odesa, Ukraine

Objective: to explore the epidemiology of pediatric growth hormone deficiency (GHD) and the overall morbidity (per 10 000 children) in different geoendemic provinces of Odesa region (Ukraine).
Material and methods: clinical laboratory and epidemiological examination of pediatric GHD in 3 physiographic zones (forest-steppe zone, steppe zone, inter-fluves zone) and in 2 geoendemic provinces of Odesa region (on the territory of Ananivskyi and Liubashevskyi districts).
Results. The pediatric population (0–17 years) in Odesa region at the end of 2016 included 450,622. Among them 43 children with GHD were followed up in the Endocrinology Department of Odesa Regional Children's Hospital. The total incidence (TI) of GHD in Odesa region compiled 0.95. The GHD prevalence ratio (PR) (ratio of sick children with GHD to the general population of children) was (43:450,622 or 1:10,400). There were 15 children with GHD among 153,530 of the children's population in Odesa. TI compiled 0.98; PR – (15:153,530 or 1:10,200). The ratio of sick boys and girls was 2.3:1 for the region and 2:1 for Odesa. According to the physicjgraphic zones of Odesa region, this ratio was: in the forest-steppe zone – (3:1), in the steppe zone – (2:1) and in the interfluve zone — (1.7:1). The highest TI (1.67) and PR (1:5,900) of GHD in children are found in the forest-steppe zone. The lowest TI was in children from the steppe zone: (0.59), where PR compiled (1:16,700). The highest morbidity is noted in the so-called «geoendemic provinces» located at the fault zones of the Earth's crust in north part of Odesa region. GHD is underdiagnosed and detectability is associated with several age"related «waves»: at the age of 5–6 years; 10–12 years and 12-14 years.
Conclusion. The heterogeneity GHD prevalence in various physicographical zones of Odesa region requires further study of the possible connection of the disease with geoendemic provinces and ecological features of areas.
Key words: growth hormone deficiency, geoendemic provinces, epidemiology of GHD.


1. Kashin-Bek disease. http://www.eurolab.ua/diseases/2209/ (date of the last accession 05/05/2017).

2. Introduction to Medical Geology. Edited by I Rudko, AN Adamenko. (2010). M, Publishing house Akadempres. 2: 448. ISBN 978-966-7541-05-7

3. Information about the Odessa region. http://odessa.ukr-prom.com/about.php (the date of the last accession on April 28, 2017).

4. Cadastres and atlas of maps of medical-geological anomalies in the territory of the Odessa region. Collective of Authors. (1991). Odessa: 177.

5. Сlinical protocols of medical care for a healthy child under 3 years. MOH Ukraine No.149 from 20.03.2008.

6. Ognev VА, Pomogaybo EB. (2016). Methodical development for teachers to conduct a practical lesson on the topic "Medical and social problems of morbidity: types and analysis of morbidity". Kharkov National Medical Institute. Kharkov, KhNMU: 38.

7. The endemic focus. Medical Encyclopedia . Electronic resource . Access mode: http://www.medical-enc.ru/14/ochag_endemic.shtml (the date of the last accession on 26.04.2017). (The date of the last circulation was 26.04.2017).

8. The role of cobalt in the human body. http://www.vit-amin.ru/st-kobalt (the date of the last accession on May 3, 2017).

9. Emons JA, Boersma B, Baron J, Wit JM. (2005). Catch-up growth: testing the hypothesis of delayed growth plate senescence in humans. J Pediatr. 147: 843. https://doi.org/10.1016/j.jpeds.2005.07.033; PMid:16356444

10. Nilsson O, Weise M, Landman EB et al. (2014). Evidence that estrogen hastens epiphyseal fusion and cessation of longitudinal bone growth by irreversibly depleting the number of resting zone progenitor cells in female rabbits. Endocrinology. 155: 2892. https://doi.org/10.1210/en.2013-2175; PMid:24708243 PMCid:PMC4098010

11. Furuki K, Toyo'oka T, Yamaguchi H. (2017, May 19). A novel rapid analysis using mass spectrometry to evaluate downstream refolding of recombinant human insulin-like growth factor-1 (mecasermin). Rapid Commun Mass Spectrom. https://doi.org/10.1002/rcm.7906. PMID:28523846

12. Sederquist B, Fernandez-Vojvodich P, Zaman F, Sävendahl L. (2014). Recent research on the growth plate: Impact of inflammatory cytokines on longitudinal bone growth. J Mol Endocrinol. 53: T35. https://doi.org/10.1530/JME-14-0006; PMid:24711646

13. Rogol AD. Causes of short stature. https://goo.gl/4WtcyU.

14. Krakow D, Rimoin DL. (2010, June). The skeletal dysplasia. Genetics IN Medicine. 12; 6: 327–341. https://doi.org/10.1097/GIM.0b013e3181daae9b; PMid:20556869