• Geoendemic evaluation of clinical and epidemiological features of growth hormone deficiency in children of Odesa region based on the 15-year monitoring

Geoendemic evaluation of clinical and epidemiological features of growth hormone deficiency in children of Odesa region based on the 15-year monitoring

PERINATOLOGY AND PEDIATRIC. UKRAINE. 2017.3(71):81-86; doi 10.15574/PP.2017.71.81

Ariaiev M. L., Biriukov V. S., Senkovska L. I., Gudz V. A., Luchnikova T. V.
Odesa National Medical University, Odesa, Ukraine
Odesa Regional Children's Clinical Hospital, Odesa, Ukraine

Objective: to explore the epidemiology of pediatric growth hormone deficiency (GHD) and the overall morbidity (per 10 000 children) in different geoendemic provinces of Odesa region (Ukraine).
Material and methods: clinical laboratory and epidemiological examination of pediatric GHD in 3 physiographic zones (forest-steppe zone, steppe zone, inter-fluves zone) and in 2 geoendemic provinces of Odesa region (on the territory of Ananivskyi and Liubashevskyi districts).
Results. The pediatric population (0–17 years) in Odesa region at the end of 2016 included 450,622. Among them 43 children with GHD were followed up in the Endocrinology Department of Odesa Regional Children's Hospital. The total incidence (TI) of GHD in Odesa region compiled 0.95. The GHD prevalence ratio (PR) (ratio of sick children with GHD to the general population of children) was (43:450,622 or 1:10,400). There were 15 children with GHD among 153,530 of the children's population in Odesa. TI compiled 0.98; PR – (15:153,530 or 1:10,200). The ratio of sick boys and girls was 2.3:1 for the region and 2:1 for Odesa. According to the physicjgraphic zones of Odesa region, this ratio was: in the forest-steppe zone – (3:1), in the steppe zone – (2:1) and in the interfluve zone — (1.7:1). The highest TI (1.67) and PR (1:5,900) of GHD in children are found in the forest-steppe zone. The lowest TI was in children from the steppe zone: (0.59), where PR compiled (1:16,700). The highest morbidity is noted in the so-called «geoendemic provinces» located at the fault zones of the Earth's crust in north part of Odesa region. GHD is underdiagnosed and detectability is associated with several age"related «waves»: at the age of 5–6 years; 10–12 years and 12-14 years.
Conclusion. The heterogeneity GHD prevalence in various physicographical zones of Odesa region requires further study of the possible connection of the disease with geoendemic provinces and ecological features of areas.
Key words: growth hormone deficiency, geoendemic provinces, epidemiology of GHD.

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