• Genetic markers, which define the occurrence and course of bronchial asthma in children 
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Genetic markers, which define the occurrence and course of bronchial asthma in children 

SOVREMENNAYA PEDIATRIYA.2016.2(74):100-104; doi 10.15574/SP.2016.74.100 

Genetic markers, which define the occurrence and course of bronchial asthma in children 

Banadyha N. V., Voloshyn S. B.

Ternopil State Medical University named after I.Ya. Horbachevsky of the Ministry of Public Health of Ukraine 

Purpose: to analyze the frequency of polymorphic loci associations rs 1042713 (Arg16Gly) of ADRβ2 gene in children with bronchial asthma.

                                                         
Patients and methods: 
in-depth clinical examination using the special methods of investigation, conducted to 62 children suffering from bronchial asthma.


The results of investigation. As a result of depth collection of anamnesis, it was revealed that in 73.68% of patients the anamnesis was unburdened. Among the examined patients, bronchial asthma manifested at the early age in 18 children (33.96%) in preschool age in 17 children (32.08%), and in a primary school in 18 children (33.96%). The early debut of disease associated with genotype Arg16Gly, while late manifestation observed in children with genotype Gly16Gly. Mostly the family inheritance depends on mother health, regardless of the severity of bronchial asthma. Іt was found that in both types of inheritance (paternal and maternal) dominated genotype Arg16Gly. Found that girls often associated with asthma genotype Gly16Gly (56.52%) and Arg16Gly (39.13%) while the boys with genotype Arg16Gly (53.84%), less with Gly16Gly (38.89%). However, genotype Arg16Arg was observed in individual patients and in the case of intermittent disease. In case of allergen-induced and virus-induced phenotypes the genotype Arg16Gly was more often diagnosed. It was clarified that intermittent flow associated with two genotypes: Arg16Gly (47.37%) and Gly16Gly (42.11%). The persistent mild course of bronchial asthma replied to genotype Gly16Gly (64.71%), but with moderate persistent — to Arg16Gly (57.69%). A good bronchodilator response was observed in patients with genotype diagnosed Arg16Gly and Gly16Gly. At the same time, patients with genotype Arg16Arg ADRβ2 needed the use of combined drugs to overcome the attack.


Conclusions: Allelic polymorphism differences of ADRβ2 gene in children with asthma were diagnosed and it indicates that dependence of debut was genetically based as well as the severity of the disease and sensitivity of receptors for emergency care facilities (β2-agonists of short action).


Key words: genetic markers, children, bronchial asthma.


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