- Functional status of hypothalamo-pituitary-adrenal axis of pregnant women with regard to their psychoemotional status
Functional status of hypothalamo-pituitary-adrenal axis of pregnant women with regard to their psychoemotional status
PERINATOLOGY AND PEDIATRIC. UKRAINE. 2017.3(71):50-55; doi 10.15574/PP.2017.71.50
Syusyuka V. G.
Zaporizhzhia State Medical University, Ukraine
Objective — to estimate functional status of hypothalamo-pituitary-adrenal axis of pregnant women with regard to their psychoemotional status.
Material and methods. There were examined 86 pregnant women in ІІ and ІІІ trimester (22-33 weeks). The main group comprises 60 pregnant women with medium and high level of state anxiety. The control group comprises 26 pregnant women with anxiety level of 30 points and less that stipulates the low level of state anxiety. Spielberger-Hanin scale was used for estimation of state anxiety and trait anxiety. Quantitative assessment of concentration of adrenocorticotropic hormone, cortisol, free testosterone, androstenedione, dehydroepiandrosterone sulphate and 17-α-ОН-progesterone hormones in blood plasma was determined by using the method of enzyme immunoassay with SIRIO S device.
Results. Comparing concentrations of adrenocorticotropic hormone, 17-α-ОН-progesterone, free testosterone, androstenedione, there was not revealed statistically reliable difference (p>0.05) between pregnant women with medium-high and low levels of state anxiety. However availability of correlation between trait anxiety and level of adrenocorticotropic hormone both in the main group (r=+0.381, p<0.05) and control group (r=+0.603, p>0.05) can indicate some mutual influences. Analyzing the level of cortisol and dehydroepiandrosterone sulphate there was revealed statistically reliable prevalence of their content among anxious pregnant women in comparison with those of low level of state anxiety. Availability of correlation between state anxiety and cortisol level is confirmed by the positive correlation (r=+0.704, p<0.05). Confirmation of the stress protective action of dehydroepiandrosterone sulphate concerning cortisol can be lack of statistically reliable difference (p>0.05) as to their correlation in both groups as well as availability of the positive correlation both in the main group (r=+0.256, p<0.05) and control group (r=+0.516, p<0.05).
Conclusions. The performed research indicates the lack of statistically reliable difference (p>0.05) for the level of adrenocorticotropic hormone, 17-α-ОН-progesterone, androstenedione and free testosterone with regard to anxiety level. However gestation course of anxious pregnants is accompanied by statistically reliable cortisol concentration increase (p<0.05) that is the sign of emotional reaction on stress situation and increase of dehydroepiandrosterone sulphate level, which has antiglucocorticoid properties.
Key words: pregnancy, psychoemotional status, anxiety, hormones, hypothalamo-pituitary-adrenal axis.
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