• Functional disorders of the gastrointestinal tract in young children

Functional disorders of the gastrointestinal tract in young children

SOVREMENNAYA PEDIATRIYA.2018.5(93):55-64

Maidannyk V. G.
Bogomolets National Medical University, Kyiv, Ukraine
Article was published in Zdorovia Ukrainy. Pediatriia. 2018. №3.

Functional disorders of the digestive system (FDDS) is a common problem in children. FDDS emerge due to a violation of microbial ecology of the gastrointestinal tract. In recent years, in the comprehensive treatment of pathological conditions associated with the microflora disorders, probiotic agents are the wellestablished practice. As probiotics, some species of lactic acid bacteria (Lactobacillus), bifidobacteria (Bifidobacterium), saccharomycetes (Saccharomyces cerevisiae), Escherichia coli (E. coli), and certain types of bacilli (Bacillus) are most commonly used. In this aspect, one of the most prospective are bifidobacteria, particularly the strain Bifidobacterium animalis subsp. lactis (BB-12). It is proved that regular intake of Bifidobacterium animalis subsp. lactis efficiently reduces the frequency and severity of FDDS symptoms (mainly diarrhoea) associated with a violation of normal intestinal microflora. Bifidobacterium animalis subsp. lactis (BB-12, strain DSM15954) forms the basis of the pharmaceutical product group Linex.

Key words: functional disorders of the digestive system, children, microflora, probitics, bifidobacteria.

REFERENCES

1. Belmer SV, Pechkurov DV. (2016). Rimskiy konsensus IV: Sovremennyiy vzglyad na funktsionalnyie rasstroystva organov pischevareniya. Voprosyi detskoy dietologii. (5):42–49.

2. Dobrovolskiy OV, Serebrova SYu. (2007). Terapiya yazvennoy bolezni i problemyi sohraneniya mikroekologii zheludochno-kishechnogo trakta. Russkiy Meditsinskiy Zhurnal. 15(16): 1193–1198.

3. Zhihareva NS, Havkin AI. (2006). Terapiya antibiotik-assotsiirovannogo disbakterioza. RMZh. 14 (19).

4. Maydannik VG. (2012). Antibiotiko-assotsiirovannaya diareya u detey. Kiev: VD Avanpost-Prim: 250.

5. Maidannyk VH. (2016). Rymski kryterii IV (2016): Shcho novoho? Mizhnarodnyi zhurnal pediatrii, akusherstva ta hinekolohii. 10(1): 8–18.

6. Maydannik VG. (2017). Narusheniya tserebro-intestinalnogo vzaimodeystviya: terminologiya novaya, problema staraya. Voprosyi prakticheskoy pediatrii. 12(1): 28–36.

7. O dIeticheskom' znachenIi «kislago moloka» prof. Mechnikova. KlinicheskIya nablyudenIya iz' SPB. Morskogo Gospitalya, doktora med. G. A. Makarova. S.-Peterburg'. IzdanIe K. L. Rikkera. NevskIy pr., 14. 1907.

8. Sichinava IV, Gorelov AV, Kanner EV. (2011). Lineks v lechenii antibiotik-assotsiirovannoy dispepsii u detey s gastroduodenitami pri antihelikobakternoy terapii. Gastroenterologiya Sankt-Peterburga. 2—3: 16—18.

9. Havkin AI, Zhihareva NS, Rachkova NS. (2005). Covremennyie printsipyi terapii yazvennoy bolezni. Lechaschiy vrach. 2: 30—33.

10. Havkin AI, Keshishyan ES. (2014). Effektivnost probiotika Bifidobacterium (Bifidobacterium animalis subsp. lactis) shtamm DSM N15954 pri funktsionalnyih narusheniyah pischevareniya u detey rannego vozrasta: rezultatyi prospektivnogo, otkryitogo, nablyudatelnogo issledovaniya. Voprosyi detskoy dietologii. 12(2): 30—36.

11. Shenvald S, Tsar V. (1984). Rezultat odinarnogo platsebo-kontroliruemogo klinicheskogo ispyitaniya lineksa. Moskva: Indok Lek.

12. Shulpekova YuO. (2003). Primenenie probiotikov v klinicheskoy praktike. RMZh. 5(1).

13. Benninga MA, Nurko S, Faure C et al. (2016). Childhood functional gastrointestinal disorders: neonate/toddler. Gastroenterology. 150(6):1443—1455.

14. Chouraqui JP, van Egroo LD, Fichot MC. (2004). Acidified milk formula supplemented with Bifidobacterium lactis: Impact on infant diarrhea in residential care settings. J Pediatr Gastroenterol Nutr. 38: 288—292.

15. Drossman DA. (2016). Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features, and Rome IV. Gastroenterology. 150(6): 1262—1279.

16. Eskesen D, Jespersen L, Michelsen B et al. (2015). Effect of the probiotic strain Bifidobacterium animalis subsp. lactis, BB-12®, on defecation frequency in healthy subjects with low defecation frequency and abdominal discomfort: a randomised, double-blind, placebo-controlled, parallel-group trial. Br J Nutrit. 114 (10): 1638—1646.

17. FAO. Food and Agriculture Organization of the United Nations. Guidelines for the evaluation of probiotics in food (2009). 27.01.2009.

18. FAO. Guidelines for the evaluation of probiotics in food. Report of a Joint FAO/WHO Working Group on Drafting Gidelines for the evaluation of probiotics in food (2002). 30.04—01.05.2002, London, Ontario, Kanada.

19. Fuller R. (1989). Probiotics in man and animals. J Appl Bacteriol. 66: 365—378.

20. Fuller R. (2004). What is a probiotic? Biologist. 51: 232.

21. Guarner F, Schaafsma GJ. (1998). Probiotics. Int J Food Microbiol. 39: 237—238. doi 10.1016/S0168-1605(97)00136-0.

22. Havenaar R, Huis In't Veld JHJ. (1992). Probiotics: a general view. In: Wood BJB (Editor). Lactic acid bacteria in health and disease. London: Elsevier Applied Science Publishers: 151—170.

23. Hill C, Guarner F, Reid G et al. (2014). Sanders expert consensus document: the International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 11: 506—514.

24. Hyams JS, Di Lorenzo C, Saps M et al. (2016). Functional gastrointestinal disorders: child/adolescent. Gastroenterology. 150(6):1456—1468.

25. Johnson CL, Versalovic J. (2012). The human microbiome and its potential importance to pediatrics. Pediatrics. 129 :950—960.

26. Jungersen M, Wind A, Johansen E. et al. (2014). The Science behind the Probiotic Strain Bifidobacterium animalis subsp. Lactis BB-12®. Microorganisms. 2(2): 92—110.

27. Lilley DM, Stillwell RH. (1965). Probiotics: growth promoting factors produced by microorganisms. Science. 147:747—748.

28. Lilly DM, Stillwell RH. (1965). Probiotics: growth promoting factors produced by microorganisms. Science. 147: 747—748.

29. Markowiak P, Slizewska R. (2018). The role of probiotics, prebiotics and synbiotics in animal nutrition. Gut Pathog. 10:21.

30. Metchnikoff E. (1908). Compt. Rend. Acad. Sci. (Paris). 147:575—582.

31. Mohan R, Koebnick C, Schildt J et al. (2006). Effects of Bifidobacterium lactis Bb12 Supplementation on Intestinal Microbiota of Preterm Infants: a Double-Blind, Placebo-Controlled, Randomized Study. J Clin Microbiol. 44(11): 4025—4031.

32. Naidu AS, Bidlack WR, Clemens RA. (1999). Probiotic spectra of lactic acid bacteria (LAB). Crit Rev Food Sci Nutr. 39 :13—126.

33. Parker RB. (1974). Probiotics, the other half of the antibiotic story. Anim Nutr Health. 29 :4—8.

34. Saavedra JM, Bauman NA, Oung I et al. (1994). Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus. Lancet. 344 (8929): 1046—1049.

35. Salminen S. (1996). Uniqueness of probiotic strains. Int Dairy Fed Nutr Newsl. 5:16—18.

36. Sanders ME. (2009). How do we know when something called «probiotic» is really a probiotic? A guideline for consumers and health professionals. Funct Food Rev. 1: 3—12.

37. Schaafsama G. (1996). State-of-the-art concerning probiotic strains in milk products. Int Dairy Fed Nutr Newsl. 5: 23—24.

38. Schrezenmeir J, dr Vrese M. (2001). Probiotics, prebiotics and synbiotics-approaching a definition. Am Soc Clin Nutr. 73: 361—364.

39. Simpson MR, Dotterud CK, Storro O et al. (2015). Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial. BMC Dermatol. 15(1): 13.

40. Sperti GS. (1971). Probiotics. West Point (CT): AVI Publishing Co. 41. Taipale T, Pienihakkinen K, Isolauri E et al. (2011). Bifidobacterium animalis subsp. lactis Bb-12 in reducing the risk of infections in infancy. Br J Nutr. 105(3): 409—416.

42. Vandenplas Y, De Greef E, Devreker T et al. (2013). Probiotics and Prebiotics in Infants and Children. Curr Infect Dis Rep. 15(3): 251—262.

43. Yang Y, Guo Y, Kan Q et al. (2014). A meta-analysis of probiotics for preventing necrotizing enterocolitis in preterm neonates. Braz J Med Biol Res. 47 (9): 804—810.