• Functional activity of the serotoninergic and pituitary3thyroid system in young children with neurological disorders and retardation of neuropsychological development 
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Functional activity of the serotoninergic and pituitary3thyroid system in young children with neurological disorders and retardation of neuropsychological development 

SOVREMENNAYA PEDIATRIYA.2015.7(71):111-114; doi 10.15574/SP.2015.71.111 
 

Functional activity of the serotoninergic and pituitary3thyroid system in young children with neurological disorders and retardation of neuropsychological development 
 

Mamenko M. E., Shleyenkova A. A.

P.L. Shupyk National Medical Academy of Postgraduate Education, Kiev, Ukraine,

Kharkov Medical Academy of Postgraduate Education, Kharkov, Ukraine 
 

Objective. To study the functional activity of serotonin and pituitary-thyroid system and to evaluate their impact on mental development of young children. 
 

Materials and Methods. In the original survey 123 children aged from 2 to 3.5 months participated, which came to the nurture children's home during the period from 2010 to 2012 as children deprived of parental care. The neurological status, mental development index (IMD), the levels of TSH, free T4 and serotonin were assessed. 
 

Results. Children from the orphanage had a high incidence of neurological disorders (94.1±2.2%). The syndrome of static, kinetic, mental and pre-speech retardation dominated in structure of neurological disorders (49.2±4.7 %, p<0.001). These children often demonstrate elevated levels of TSH (more than 4.0 mU/l) and serotonin (the median of serotonin was 202.2 nmol/ml vs 184.9 nmol/ml in children without disorders of the nervous system (p=0.049). 
 

Conclusions. High frequency disturbances of mental development was accompanied by a reduction in the functional activity of the pituitary-thyroid system and the activation of serotonin system. The moderate level of direct correlation between levels of TSH and serotonin was demonstrated (р=0.56). Increased production of serotonin can be considered as a reaction of adaptation to compensate the effects of thyroid insufficiency. 
 

Key words: neurological status; neuropsychological development; pituitary-thyroid system; serotonin, young children. 
 

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