• Food intolerance in the pathogenesis of functional gastrointestinal disorders in infants: approaches to diagnosis and treatment 
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Food intolerance in the pathogenesis of functional gastrointestinal disorders in infants: approaches to diagnosis and treatment 

PERINATOLOGIYA I PEDIATRIYA.2016.1(65):104-111;doi 10.15574/PP.2016.65.104 

Food intolerance in the pathogenesis of functional gastrointestinal disorders in infants: approaches to diagnosis and treatment 

Shadrin O. G., Marushko T. L., Radushinskaya T. Yu., Marushko R. V., Fisun V. N., Kovalchuk A. A., Bondarenko N. Y.

SI «Institute of pediatrics, obstetrics and gynecology NAMS of Ukraine», Kyiv, Ukraine 

Purpose — to study the clinical and paraclinical features of gastrointestinal manifestations of food intolerance and improve the efficiency of their treatment. 

Patients and methods. Among 147 infants with functional gastrointestinal disorders based on clinical and paraclinical examinations, identified 65 patients with gastrointestinal disorders caused by food intoleranc. Depending on the plan of the treatment, children with food intolerance were divided into two groups — the main group (40 children apart form symptomatic treatment received treatment for the main disease) and control group (25 children who received only symptomatic treatment according to the protocols). 

Results. In 44.2% of young children with gastrointestinal disorders was revealed food intolerance (non-allergic food hypersensitivity). Combination of symptomatic treatment (simethicone, prokinetics, spasmolytics, etc.) and treatment of the main disease (depending on the cause of food intolerance — enzymes, cholagogic preparation, probiotics, etc.) in the complex therapy allowed to eleminate or significantly reduce the intensity of clinical manifestations of gastrointestinal disorders in 90% of children of main group. 

Conclusions. Gastrointestinal disorders in children with food intolerances are not clinically different from functional gastrointestinal diseases, but are characterized by high intensity, combination of various gastrointestinal disorders, lack of efficiency of symptomatic treatment. To improve the efficiency of treatment in children with secondary gastrointestinal disorders, it is required the timely appropriate diagnostics of food intolerance and the treatment of underlying disease. 

Key words: infants, gastrointestinal tract, functional disorders, food intolerance, treatment. 


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