• Folate deficiency and the role of its correction in prevention of obstetric and perinatal complications
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Folate deficiency and the role of its correction in prevention of obstetric and perinatal complications

PERINATOLOGY AND PEDIATRIC. UKRAINE. 2018.1(73):63-68; doi 10.15574/PP.2018.73.63

Yu.V. Davydova
SI «Institute of Pediatrics, Obstetrics and Gynaecology of NAMS of Ukraine», Kyiv, Ukraine

The role of preconceptional prevention of folate deficiency is much more than the prevention of congenital malformations only, however, a differentiated approach to the choice of drugs and the duration of their use is necessary. For the prevention of deficiency in women who are planning pregnancy, pregnants and those who breast-feed can only use vitamin-mineral complexes registered as therapeutic pharmaceutical agent with proven efficiency and a high safety profile. The modern vitamin-mineral complex Elevit® Pronatal fully complies with these requirements.
Key words: pregnancy, folic acid, prevention of deficiency, vitamin#mineral complex.


1. Behrman RE, Butler AS (Eds). (2007). Preterm Birth: Causes, Consequences, and Prevention. Institute of Medicine. Washington, DC: The National Academies Press.

2. Bentley S, Hermes A, Phillips D et al. (2011). Comparative effectiveness of a prenatal medical food to prenatal vitamins on hemoglobin levels and adverse outcomes: a retrospective analysis. Clin Therapeut.33:204–210. https://doi.org/10.1016/j.clinthera.2011.02.010; PMid:21440300

3. Bodnar LM, Himes KP, Venkataramanan R et al. (2010). Maternal serum folate species in early pregnancy and risk of preterm birth. Am J Clin Nutr.92:864–871. https://doi.org/10.3945/ajcn.2010.29675; PMid:20739422 PMCid:PMC2937585

4. Bukowski R, Malone FD, Porter FT et al. (2009). Preconceptional folate supplementation and the risk of spontaneous preterm birth: a cohort study. PLoS Med.6:e1000061. https://doi.org/10.1371/journal.pmed.1000061; PMid:19434228 PMCid:PMC2671168

5. Czeizel AE. (2000). Primary prevention of neural-tube defects and some other major congenital abnormalities: recommendations for the appropriate use of folic acid during pregnancy. Paediatr Drugs.2(6):437–49. https://doi.org/10.2165/00128072-200002060-00003; PMid:11127844

6. De Regil LM, Fernandez-Gaxiola AC, Dowswell T, Pena-Rosas JP. (2010). Effects and safety of periconceptional folate supplementation for preventing birth defects. Cochrane Database Syst Rev. CD007950. https://doi.org/10.1002/14651858.CD007950.pub2; PMid:20927767 PMCid:PMC4160020

7. Ministry of Health. (2006). Food and Nutrition Guidelines for Healthy Pregnant and Breastfeeding Women. A background paper. Wellington: Ministry of Health, New Zealand.

8. Safi J, Joyeux L, Chalouhi GE. (2012). Periconceptional Folate Deficiency and Implications in Neural Tube Defects. Journal of Pregnancy. 2012. Article ID 295083https://doi.org/10.1155/2012/295083; PMid:22900183 PMCid:PMC3415073

9. Talaulikar VS, Arulkumaran S. (2011).Folic acid in obstetric practice: a review, Obstetrical and Gynecological Survey.66.4:240–247. https://doi.org/10.1097/OGX.0b013e318223614c; PMid:21756406

10. Wilson RD, Johnson JA, Wyatt P et al. (2007). Genetics Committee of the Society of Obstetricians and Gynaecologists of Canada and The Mother-risk Program. Pre%conceptional vitamin/folic acid supplementation 2007: the use of folic acid in combination with a multivitamin supplement for the prevention of neural tube defects and other congenital anomalies. J Obstet Gynaecol Can.29:1003–1026. https://doi.org/10.1016/S1701-2163(16)32685-8