• Flow-mediated dilationin women with initial manifestations of cerebral ischemia 
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Flow-mediated dilationin women with initial manifestations of cerebral ischemia 

HEALTH OF WOMAN. 2016.2(108):56–59 

Flow-mediated dilationin women with initial manifestations of cerebral ischemia 

Trishchynska М.

National Medical Academy of Postgraduate Education P. L. Shupyk, Kiev 

Cerebrovascular pathology leads to significant disability, not only the elderly, but also the able-bodied population.Vascular endothelial function can be one of the most promising targets to influence the development of chronic cerebral ischemia (CCI).

We carried out a study whose purpose was to study and comparative assessment of vasomotor endothelial function in patients with initial manifestations CCI according to the degreeof structural brain damage.

Material and methods. We examined 306 patients with initial manifestations of CCI – with vascular risk factors (VRF), the relevant clinical manifestations and neuroimaging signs of mild lesions of the brain.Among the examined patients was 27,8% men and 72.2% women. The average age of patients was 50.6±7.8 years.

Patients were divided into two groups depending on visualization changes of the brain probably vascular origin, and patients of Group 2 were divided into two (A and B) groups too according to the presence of cerebral atrophy. All patients conducted general clinical, clinical-neurological, instrumental and clinical laboratory tests.In order to study endothelial functionpatients underwent flow-mediated dilation (FMD) test with a percentage and the index of vasodilatation (IEV) calculation.

Results. Patients of different groups is statistically significant (p <0.001) differed in terms of FMD obtained during the compression test.As the degree of brain lesions in the initial manifestations of CCI observed decrease in the percentage and the IEV, and more patients had widespread endothelial dysfunction (Me (Q1-Q3) FMD percent in group 1 – 13.8 (10.0–17.6) whereas in group 2B – 7.3 (5.8–9.4).

Among hypertensive patients most pronounced changes in the endothelial dysfunction observed in patients with hypertension stage II (9.5 (6.7–11.4). Office systolic (r=-0.340) and diastolic (r=-0.301) blood pressure was significantly (p <0.001) correlated with IEV patients studied.

Conclusions. 1. Percentage of FMD and IEV significantly decreased with increasing severity of brain lesions in patients with initial manifestations of CCI. 2. The greatest number of patients with evidence of ED was common among patients with initial signs of neuroimaging cerebral atrophy, with hypertension, namely hypertension stage II. 3. The relationship between the degree of increase in blood pressure and the presence of a common ED had relatively low density and thus of questionable clinical significance.

Key words: flow-mediated vasodilatation, the initial manifestations of chronic brain ischemia, hypertension, endothelial dysfunction.


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