• Features of vitamin D status in children with chronic hepatitis C

Features of vitamin D status in children with chronic hepatitis C

PERINATOLOGY AND PEDIATRIC. UKRAINE. 2018.3(75):76-81; doi 10.15574/PP.2018.75.76

Berezenko V. S., Tkalyk O. М., Dyba M. B., Krat V. V., Mykhayluk K. Z.
SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine, Kyiv

Objective: to study features of vitamin D status of children with chronic hepatitis C depending upon age, gender, seasonality, place of residence and activity of hepatitis.

Materials and methods. In total 28 children with chronic hepatitis C were examined during the period of 2015–2018. A complex of laboratory tests in accordance with the protocol was conducted. To verify the vitamin D status, the 25(OH)D3 serum concentration was determined. The peculiarities of vitamin D status in children depending upon gender, age, seasonality, place of residence were studied, as well as the activity of hepatitis.

Results. In the majority of children that made up 60.7% (n=17) a vitamin D level decrease was detected, in 28.6% (n=8) of which insufficiency was diagnosed and deficiency – in 32.1% (n=9). The optimum vitamin D level was found in 39.3% (n=11) of children. The average vitamin D level in children with chronic hepatitis C constituted 23.05 [15.44–38.05] ng/mL and showed its insufficiency. It was found that the optimum vitamin D level was significantly more frequently observed in children with inactive hepatitis as compared to the group of children with ALT-3N (χ2=3.97, р=0.04). A significant negative correlation was found between the activity of hepatitis and vitamin D concentration in the blood serum of children with chronic hepatitis С (R<0.4; p=0.03). No influence of gender, age, place of residence and seasonality on the vitamin D status in the examined children with chronic hepatitis С (p>0.05) revealed.

Conclusions. In the majority (60.7%) of children with chronic hepatitis C, a reduced 25(OH)D in serum was revealed. It is shown that vitamin D status in children with this disease had an inverse correlation with the biochemical activity of hepatitis (according to transaminases level). There was no statistically significant difference between the vitamin D status of children with chronic hepatitis C, depending upon gender, age, seasonality and place of residence.

Key words: children, chronic hepatitis C, vitamin D, hepatitis activity.

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Article received: May 15, 2018. Accepted for publication: Aug 29, 2018.