- Features of vitamin D status in children with autoimmune hepatitis
Features of vitamin D status in children with autoimmune hepatitis
PERINATOLOGY AND PEDIATRIC. UKRAINE. 2018.1(73):92-97; doi 10.15574/PP.2018.73.92
Berezenko V. S., Mykhayluk K. Z., Shadrin V. O., Krat V. V.
SI «Institute of Pediatrics, Obstetrics and Gynaecology of NAMS of Ukraine», Kyiv, Ukraine
Bogomolets National Medical University, Kyiv, Ukraine
Objective — to study features of vitamin D status in children with autoimmune hepatitis.
Material and methods. In total 30 children with autoimmune hepatitis were examined during the period of 2015–2017. All children were provided with comprehensive laboratory tests in accordance with the protocol and puncture biopsy of the liver with a morphological study of the biopsy specimen. To verify the diagnosis of vitamin D deficiency, the 25(OH)D serum concentration was determined. The peculiarities of vitamin D status in children with autoimmune hepatitis depending upon the disease activity degree, gender, age, seasonality, and geographical location of place of residence were studied. The children who were not administered calcium and vitamin D supplementation for 6 months were enrolled.
Results. The majority of children — 80% (n=24) — had vitamin D deficiency, its insufficiency was noted in 13.3% (n=4) of those surveyed, optimal level of vitamin D revealed 6.7% (n=2) of children. The average level of vitamin D in children with autoimmune hepatitis was in the deficit and made up 12.3 [10.0–19.84] ng/mL. It was revealed that children with vitamin D deficiency had significantly higher activity of the inflammatory process in the liver (χ2=12.59, p<0.01 compared to the groups of children with minimal and high biochemical activity) according to the results of the biochemical blood analysis. No influence of gender, age, region of residence and seasonality on the vitamin D status in the examined children with autoimmune hepatitis (p>0.05) detected.
Conclusions. The vitamin D levels depend upon the biochemical activity of hepatitis. Children with high activity of hepatitis have a significantly lower vitamin D level. There was no statistically significant difference between the vitamin D status of children with autoimmune hepatitis, depending upon gender, age, seasonality and place of residence.
Key words: autoimmune hepatitis, children, vitamin D, activity of hepatitis
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