• Features of immune correction in children with pyelonephritis depending on the manifestations of undifferentiated connective tissue dysplasia

Features of immune correction in children with pyelonephritis depending on the manifestations of undifferentiated connective tissue dysplasia

SOVREMENNAYA PEDIATRIYA.2017.7(87):85-89; doi 10.15574/SP.2017.87.85

Melnychuk L. V.
Ivano-Frankivsk Regional Children's Clinical Hospital, Ukraine

Pyelonephritis is a common kidney disease, which has a tendency towards chronization and formation of complications. An adequate managment of patients with pyelonephritis should consider etiological factors and symptoms of the disease as well as individual risk factors and pathogenetic mechanisms.

The objective of the research was to study the efficacy of combination therapy with inclusion of multivitamin and multienzyme preparations in children with pyelonephritis depending on the presence of undifferentiated connective tissue dysplasia manifestations.

Material and methods. The study included 96 children with pyelonephritis aged from 3 to 15 years (the average age was 8.6±1.4 years). The control group included 20 apparently healthy children of the same age. The studied patients were divided according to the presence of connective tissue dysplasia and the method of treatment.

Results and discussion. In children with pyelonephritis and signs of undifferentiated connective tissue dysplasia, after the routine treatment the level of tumor necrosis factor-alpha reduced insignificantly (p>0.05), while the dynamics of endotoxemia indicators, such as interleukin 10, interleukin 8, underwent significant changes (p<0.05). The latter was noted on the background of multivitamin preparation usage (p<0.05). However, the best dynamics of the cytokine status and endotoxemia was observed in children receiving multienzyme and its combination with multivitamin and basic treatment — in undifferentiated connective tissue dysplasia (p<0.01) and without it (p<0.001).

Conclusions. In both groups of children with pyelonephritis and undifferentiated connective tissue dysplasia signs and those with pyelonephritis and no signs of undifferentiated connective tissue dysplasia, therapeutic complexes using multienzyme preparation, as well as its combination with multivitamin preparation on the background of basic therapy, turned out to be the most effective in reducing systemic immunoinflammatory response and endotoxemia. In the presence or absence of connective tissue dysplasia, under the influence of these therapeutic complexes, the production of interleukin 10 increased, while the synthesis of interleukin 8, tumor necrosis factor and endotoxemia reduced.

Key words: pyelonephritis, connective tissue dysplasia, cytokines, treatment.

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