- Features of the exocrine pancreatic function and lactose intolerance in premature babies
Features of the exocrine pancreatic function and lactose intolerance in premature babies
SOVREMENNAYA PEDIATRIYA.2018.8(96):42-49; doi 10.15574/SP.2018.96.42
Khasanova S. S., Kamilova A. Т.
Republican Perinatal Center, Ministry of Health of the Republic of Uzbekistan, Tashkent
Republican Specialized Scientific and Practical Medical Center of Pediatrics, Ministry of Health of the Republic of Uzbekistan, Tashkent
In the literature there are few data on the levels of fecal elastase in premature and full-term newborns, and data on the frequency of lactase deficiency (LD) in newborns with different gestational age are contradictory.
The aim of our study was to determine the activity of pancreatic elastase and lactase in premature babies up to 32 weeks. The study included 54 children born in the period from 22 to 32 weeks of gestation and 8 healthy full-term babies (control group).
Materials and methods. All children on the 13–14th day of life, in addition to the standard examination, were determined by the analysis of feces for the presence of carbohydrates by the Benedict method and determination the level of fecal elastase (FE) using enzyme immunoassay.
Results. By the 14th day of life in children with gestational age from 22 to 27 weeks, mild pancreatic insufficiency was established, the average PE in this group was 166.6±64.6 mg/g and they were significantly different compared to the full-term infants who amounted to 326.0±26.0 mg/g (p<0.050), whereas in the group of children with gestational age at birth from 28 to 32 weeks by the end of the second week of life, the values of pancreatic elastase were significantly higher and amounted to 278.6±10,3 mg/g (p>0.050), although they were lower than the full-term data, but the difference was not reliable (t=1.72). The results of the Benedict test showed an increase in the level of limit values in 25 (46.3%) children examined.
Conclusion. The data obtained allow us to conclude that mild pancreatic insufficiency was established in premature infants with a gestational age of 22–27 weeks to two weeks of age. Lactase deficiency was recorded in 46.3% of premature babies up to 32 weeks, the clinical manifestations of the disease were not specific and were characterized by stool liquefaction.
Key words: premature babies, fecal elastase, lactose insufficiency.
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Article received: Aug 11, 2018. Accepted for publication: Dec 03, 2018.