• Fatty acid-binding proteins (FABP) as markers of gastrointestinal tract complication in children with acute neuroinfection

Fatty acid-binding proteins (FABP) as markers of gastrointestinal tract complication in children with acute neuroinfection

SOVREMENNAYA PEDIATRIYA.2017.5(85):13-18; doi 10.15574/SP.2017.85.13

Kramarov S. О., Markov А.І.
Bogomolets National Medical University, Kyiv, Ukraine

Gastrointestinal (GI) complications in children with acute CNS infections increase the risk of adverse effects and prolong the duration of treatment and period of rehabilitation.
Objective. To evaluate the frequency of GI disorders in children with an acute neuroinfection by measurement of serum intestinal fatty acid-binding protein L-FABP and I-FABP.
Material and methods. Paediatric patients with a clinical diagnosis of acute neuroinfection (meningitis, encephalitis) assessed by L-FABP and I-FABP measurement were recruited for this trial at the university hospital. Serum I-FABP and L-FABP levels were measured by an enzyme-linked immunosorbent assay using a specific monoclonal antibody.
Results. We analysed 59 history cases of children aged from 1 month to 16 years 8 months. The mean serum I-FABP and L-FABP level at the first measurement (24 hours at the time of hospital admission) was 8.39±7.89 ng/ml and 228.92±324.19 ng/ml, respectively. At the second measurement (the 6-7th day of hospital stay) I-FABP level was 7.96±6.67 ng/ml, L-FABP — 166.17±62.04 ng/ml. At the first measurement the highest mean level of I-FABP was presented in the patients with neuroinfection complicated by a cerebral oedema, and the highest L-FABP level was observed in patients with septic shock. The result of the second test revealed tendency to normalization of I-FABP and L-FABP levels in children with septic shock and cerebral oedema.
Conclusion. Acute neuroinfection in children is often associated with gastrointestinal disorders. Most significant changes are related to cerebral oedema and septic shock. Measurement of serum biomarkers I-FABP and L-FABP is useful tool to detection of GI disorders in early stages in children with an acute neuroinfection.
Keywords: I-FABP, L-FABP, neuroinfection, children, gastrointestinal complications.

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