• Evaluation of the inflammatory response kids with juvenile rheumatoid arthritis with clinical presentation of the secondary myopathy 
To content

Evaluation of the inflammatory response kids with juvenile rheumatoid arthritis with clinical presentation of the secondary myopathy 

SOVREMENNAYA PEDIATRIYA.2015.7(71):92-95; doi 10.15574/SP.2015.71.92 
 

Evaluation of the inflammatory response kids with juvenile rheumatoid arthritis with clinical presentation of the secondary myopathy 
 

Dudnyk V. M., Bereznyckyi A. V., Vyzhga Y. V.

N.I. Pirogov Vinnitsya national medical university, Ukraine 
 

The objective. To estimate characteristic of the inflammatory activity in kids with signs of the secondary myopathy in case of juvenile rheumatoid arthritis. 
 

Patients and methods. Under the control we passed examination of 72 children with JRA that were on the treatment course in Vinnitsya regional children's hospital. The average age of the patients was — 11.3 (8.6; 15.2) years. The first group was presented with 43 (68.06±4.16)% patients with JRA with clinical signs of the secondary myopathy. The second group included 29 (40.28±4.16)% patients with JRA without such clinical symptoms. 
 

Results. Clinical presentation of the joint syndrome in kids with JRA and signs of the secondary myopathy was characterized with persistent variant of the arthralgies (more 29.89±1.59)% and high frequency of the morning stiffness feelings (more 13.63±1.27)%. Currency of the JRA that followed with clinical signs of secondary myopathy was characterized with high activity with hyperproduction of the C-reactive protein (7.25 (5.45; 10.5)) mg/l and mail inflammatory cytokines — ІL-1β (7.6 (4.5; 10.9)) pg/l and IL-6 (6.8 (4.1; 7.8)) pg/l. Evaluation of the kreatinkinase-MM with high sensitivity (91.6±3.08)% can be used in rheumatology practice as marker and predictor of the development of the SM syndrome. 
 

Conclusion. Perspective is further investigations of the pathogenetic moments of the secondary myopathy origin in patients with JRA and its correlation with main clinical and laboratory signs of the activity of the process with the aim of modification of the next treatment steps. 
 

Key words: secondary myopathy, juvenile rheumatoid myopathy. 
 

REFERENCES

1. Борткевич ОП, Білявська ЮВ. 2009. Особливості перебігу ранньої стадії ревматоїдного артриту за даними 12-місячного проспективного спостереження. Український ревматол журн. 1: 40—43.

2. Матюнова АЕ, Брегель ЛВ. 2009. Факторы инвалидизации у детей с ювенильным ревматоидным артритом. Сибирский мед журн. 7: 199—202.

3. Денисова РВ, Альбицкий ВЮ, Алексеева ЕИ и др. 2008. Психометрические характеристики русских версий опросников PedsQL Rheumatology Module и PedsQL Generic Core Scale для оценки качества жизни детей в возрасте 2—4 лет, страдающих ювенильным ревматоидным артритом. Вопр совр педиатрии. 5: 39—45.

4. Justine EA, Munro JE, Ponsonby A-L. 2010. Possible Environmental Determinants of Juvenile Idiopathic Arthritis. Rheumatology. 3: 411—425.

5. Huang JL. 2012. New advances in juvenile idiopathic arthritis. Chang Gung Med J. 35: 1—14. http://dx.doi.org/10.4103/2319-4170.106171

6. Klepper SE. 2011. Measures of pediatric function: Child Health Assessment Questionnaire (C-HAQ), Juvenile Arthritis Functional Assessment Scale (JAFAS), Pediatric Outcomes Data Collection Instrument (PODCI), and Activities Scale for Kids (ASK). Arthritis Care Research. 11: 371—382. http://dx.doi.org/10.1002/acr.20635; PMid:22588758

7. Consolaro A, Bracciolini G, Ruperto N et. al. 2012. Remission, minimal disease activity, and acceptable symptom state in juvenile idiopathic arthritis: defining criteria based on the juvenile arthritis disease activity score. Arthritis Rheumatology. 7: 2366—2372. http://dx.doi.org/10.1002/art.34373; PMid:22231288