• Evaluation of efficacy and safety of Viburсol drug in threatened miscarriage 
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Evaluation of efficacy and safety of Viburсol drug in threatened miscarriage 

PERINATOLOGIYA I PEDIATRIYA. 2016.3(67):28-34; doi 10.15574/PP.2016.67.28 
 

Evaluation of efficacy and safety of Viburсol drug in threatened miscarriage 
 

Avramenko T. V., Moschich A. P.

SI «Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine», Kyiv

Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine 
 

Purpose — to compare the efficacy and tolerability of Viburcol drug (Viburcol)®, rectal suppositories, of «Biologische Heilmittel Heel GmbH», Germany, production, which is used as antispasmodic, analgesic complex bio-regulatory remedy with the reference No-X-sha drug, of JSC «Lekhim-Kharkiv» production, rectal suppositories, which is used as antispasmodic agent for threatened miscarriage.


Patients and methods. 92 pregnant women aged 19 to 40 years, who were randomized into 2 groups: the main group (n=46) and the control (n=46) one, were involved in the study. There was the following dosage regimen: the drug under study Viburcol was applied per rectum, 2 suppositories 1–3 times per day for 10–20 days as antispasmodic, analgesic and sedative in the main group in threatened miscarriage of any etiology. Antispasmodic No-X-sha (suppositories) was used under the scheme, according to the instructions, in the control group. Evaluation was based on clinical examination, laboratory tests (complete blood count and urinalysis, blood chemistry and hormonal tests), examination of vaginal mucosa, cervix, obstetric examination (uterine tonus, fundal height, the number of fetal movements, the fetal heartbeat, CTG), bimanual examination of the birth canal, that were conducted in every woman before and after treatment.


Results. The results of the 92 patients comparative study to evaluate the effectiveness of the drugs Viburcol and No-X-sha, which were used as antispasmodic, analgesic remedies, showed high clinical efficacy, good tolerability and no adverse effect on the various body systems of mother and fetus.


Conclusions. Viburcol drug is equivalent to the reference medicine No-X-sha in therapeutic efficacy and tolerability. Therefore Viburcol can be recommended for medical use as reliable antispasmodic, sedative, analgesic bio-regulatory treatment of threatened abortion.


Key words: drugs, complex bio-regulatory approach, the threatened abortion, Viburcol.


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