• Estimation of Polygynax efficiency in treatment of mixed bacterial vaginitis in women with cervical ectopy 

Estimation of Polygynax efficiency in treatment of mixed bacterial vaginitis in women with cervical ectopy 

HEALTH OF WOMAN. 2016.4(110):102–107; doi 10.15574/HW.2016.110.102 
 

Estimation of Polygynax efficiency in treatment of mixed bacterial vaginitis in women with cervical ectopy 
 

Pyrohova V., Mazur Yu., Shurpyak S., Malachinska M.

Lviv national medical University named Danylo Galitsky

MI LRC «Lviv regional center of reproductive health of the population» 
 

Aim: to estimate the efficiency of Polygynax in treatment and prevention of recurrence of cervical ectopy by vaginal dysbiosis.


Materials and methods. The research included 83 women of 20-38 years old. 25 women of reproductive aged with recurrence cervical ectopy formed basic group. Comparison group consisted of 38 persons with firstly diagnosed benign cervical pathology. 20 women without somatic and gynecological pathology who planned pregnancy were controls. Depending on the treatment patients of basic and comparison groups were randomized into the following subgroups. Persons of B-I (15 women) and C-I (20 patients) subgroups received Polygynax 1 capsular vaginally in evening for 12 days for normalize of vaginal microbiota. Women of B-II (10 persons) and C-II (18 persons) subgroups were treated according to Orders # 676 from 31.12.2004 and # 417 from 15.07.2011 Ministry of Health of Ukraine. For normalize of vaginal microbiota we used Polygynax – combined vaginal capsules containing two bactericidal antibiotics (polymyxin B sulfate and neomycin sulfate), antifungal ingredient nystatin and dimethyl polysiloxane gel.


Results. Our results suggest that after onset of sexual activity the initial physiological cervical ectopy is complicated by inflammation of vagina and cervix and development of dysbiotic genitalia processes in certain number of women in early reproductive age. Aim of pathogenetic treatment in these cases is to normalize the condition of vaginal microbiota with active observation management of pathological process and prescribe, if necessary, repeated courses of treatment. It worth to mention that aggressive treatment of uncomplicated cervical ectopy leads to inefficiency of reverse process development even by use of local antibacterial therapy which has long-term efficiency but does not remove sclerosis, scarring and microcirculatory disorders in cervical tissue. Use of Polygynax in patient with mixed bacterial and Candida vaginitis has positive long-term effect in 86.7 % of cases with recurrent cervical ectopy and in 90.0 % of persons with first diagnosed ectopy.


Conclusion. Ignoring of assessment of vaginal microbiota and providing unfounded procedures of uncomplicated cervical ectopy in young women in reproductive age lead to significant recurrence rate of cervical ectopy. Treatment with Polygynax of cervical ectopy formed after inflammation of vagina and cervix provides positive effect (disappearance of cervical ectopy) in 35 % of patients.


Key words: cervical ectopy, vaginal microbiota, Polygynax, mixed bacterial vaginitis.


REFERENCES

1. Belokrinitskaya TE, Sverdlova ES. 2011. Zabolevaniya sheyki matki: Rukovodstvo dlya vrachey. izd. 2-e, pererab. i dop. Chita:48.

2. Burtushkina NK, Kupert AF. 2011. Effektivnost radiovolnovogo metoda lecheniya dobrokachestvennyih zabolevaniy sheyki matki. Sibirskiy meditsinskiy zhurnal 2:74–76.

3. Vaganova SE. 2010. Kombinirovannoe lechenie dobrokachestvennyih zabolevaniy sheyki matki. Akusherstvo i ginekologiya 5:116–120.

4. Gavrilenko EV, Krasnozhenov EP, Agarkova LA i dr. 2008. Izmenenie mestnoy protivoinfektsionnoy zaschityi reproduktivnogo trakta u zhenschin s ektopiey sheyki matki. Sibirskiy meditsinskiy zhurnal 23;4–1:48–49.

5. Minkina GN, Rusakevich PS. 2000. Zabolevaniya sheyki matki. Minsk:260.

6. Patologiya sheyki i tela matki. Rukovodstvo dlya vrachey. Pod red. prof. Kohanevich EV. Nezhin, Gidromaks. 2009:352.

7. Prilepskaya VN. 2008. Patologiya sheyki matki i genitalnyie infektsii. M, MEDpress-inform:385.

8. Prilepskaya VN, Kostava MN. 2006. Patologiya sheyki matki: teoriya i praktika. Patologiya sheyki matki. Genitalnyie infektsii 1;3:3–6.

9. Chayka VK. 2011. Zahvoryuvannya shiyki matki: navchalniy posIbnik. Pid red. chl.-kor. NAMNU prof. Chayki VK. Donetsk:282.

10. Churuksaeva ON, Kolomiets LA. 2011. Fiziohirurgicheskie metodyi lecheniya virus-assotsiirovannoy patologii sheyki matki. Sibirskiy onkologicheskiy zhurnal 3(45):11–15.

11. Boisnic S, Branchet MC. 2012. Otsenka protivovospalitelnogo effekta preparata Polizhinaks. Med. aspektyi zdorovya zhenschinyi 4(56):22–23.

12. Sobel JD, Subramanian C, Foxman B, Fairfax M et al. 2013. Mixed vaginitis-more than coinfection and with therapeutic implications. Curr. Infect. Dis. Rep. 15;2:104–108. http://dx.doi.org/10.1007/s11908-013-0325-5; PMid:23354954

13. Tempera G, Furneri PM. 2010. Management of aerobic vaginitis. Gynecol. Obstet. Invest. 70;4:244–249. http://dx.doi.org/10.1159/000314013; PMid:21051843

14. Verriere F. 2011. Otsenka effektivnosti preparata Polizhinaks v lechenii vaginitov. Akusherstvo i ginekologiya (Bолgarsko druzhestvo po akusherstvo i ginekologiya B'lgarsko druzhestvo po akusherstvo i ginekologiya). 50:32–37.