• Epiphysis implication in chronobiological features of arterial hypertension among children.
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Epiphysis implication in chronobiological features of arterial hypertension among children.

SOVREMENNAYA PEDIATRIYA.2014.3(59):94-97; doi 10.15574/SP.2014.59.94

 

Epiphysis implication in chronobiological features of arterial hypertension among children.

 

Kaladze N. N., Zyukova I. B.

Crimea state medical university named after S.I.Georgievsky, Simferopol, Ukraine.

 

Purpose: to study conditions of a epiphysis melatonin producing function and its influence on hemodynamic indexes among children with arterial hypertension (AH).

 

Patients and methods: 132 children (aged 12-16 ) with AH were investigated. The control group included 20 healthy children. The children with AH were divided in two groups: with labile hypertension (LH) -71 (54%) and sustained hypertension (SH) – 61 (46%). All the children were clinically and laboratory examined. Melatonin level in the body was determined by the concentration of its major metabolite 6-sulfatoxymelatonin (6-SOM) in a daytime and nighttime urine sample. 2-7hour blood pressure a monitoring was conducted.

 

Results: Abnormalities of 2-7 hour AH rhythms and heart stress indices among children with hypertension indicate ratio violations of pressor and depressor mechanisms and desynchronized circadian rhythm were found. Also, cardiac arrhythmias melatonin secretion and reduction of its concentration were determined; the most pronounced imbalance of melatonin was observed among children with SH.

 

Conclusions: detected violations confirm the need to optimize the treatment of patients with arterial hypertension taking into account their biorhythmology.

 

Key words: epiphysis, melatonin, circadian rhythms, arterial hypertension, children.