PERINATOLOGIYA I PEDIATRIYA. 2016.4(68):60-62; doi 10.15574/PP.2016.68.60 
 

Epidermal growth factor and prolonged neonatal jaundice 
 

Yablon O., Mazur O.

Vinnytsya National Pirogov Memorial Medical University, Ukraine

Purpose — to determine content of serum epidermal growth factor in newborns with prolonged jaundiceand its influence on the duration of hyperbilirubinemia.

Patients and methods. The study included 50 children who were treated at the Vynnytsia regional children's hospital about prolonged jaundice in newborns, among them 27 boys and 23 girls. The comparison group consisted of 12 children with physiological jaundice — 7 boys and 5 girls. All children were breastfed.

Results. All children were full term, the mean gestational age for the main group of children was 39±0.14 weeks, the comparison group was 39±0.25 weeks (p>0.05). In the biochemical analysis of blood in children of the main group and the comparison group there was an increase in the level of total bilirubin in blood serum due to its indirect fraction: mean levels of total bilirubin in blood serum in children of the main group amounted to 280.96±10 μmol/l; in comparison group, mean levels of total bilirubin in blood serum was significantly lower — 184.7±6.8 μmol/l (p<0.05). Serum levels of EGF in children of the main group were increased in 2 times than the comparison group 393.9 [241–572] ng/ml and of 188.8 [76.3–243] ng/ml (p<0.05). The analysis of the levels of serum EGF in children depending on the duration of jaundice. So, in children with duration of jaundice of more than 1 month levels of serum EGF were 59% higher in comparison with children with the duration of jaundice in less than 1 month, respectively, to 494.6±49.7 ng/ml and 355.8±39.7 ng/ml (p<0.05).

Conclusions. In children with prolonged neonatal jaundice the levels of serum epidermal growth factor were 393.9 [241–572] ng/ml, which is 2 times higher than in children with physiological jaundice. It was determined the dependency of the rate of epidermal growth factor on the duration of jaundice: the highest levels were observed in children with duration of jaundice more than 1 month.

Key words: prolonged jaundice, epidermal growth factor, bilirubin, newborns.

References

1. Yablon OS, Mazur OH. 2016. Alpha-fetoprotein and prolonged neonatal jaundice. Neonatology, surgery and perinatal medicine. IV; 4(22): 53-56.

2. Adlard BP, Lathe GH et al. 1970. Breast milk jaundice: Effect of 3, 20pregnanediol on bilirubin conjugation by human liver. Arch Dis Child. 45: 186—189. https://doi.org/10.1136/adc.45.240.186; PMid:4246186 PMCid:PMC2020257

3. Arias IM, Gartner LM et al. 1964. Prolonged neonatal uncounjugated hyperbilirubinemia associated with breast feeding and a steroid, pregnane-3a, 20-bdiol in maternal milk that inhibits glucuronide formation in vitro. J Clin Invest. 43: 2037—2047. https://doi.org/10.1172/JCI105078; PMid:14228539 PMCid:PMC441992

4. Ohama K, Nagase H, Ogino K et al. 1997. Alphafetoprotein (AFP) levels in normal children. Eur J Pediatr Surg. 7: 267—269. https://doi.org/10.1055/s-2008-1071168; PMid:9402482

5. Kumral A, Ozkan H, Duman N et al. 2009. Breast milk jaundice correlates with high levels of epidermal growth factor. Pediatr Res. 66; 2: 218—221. https://doi.org/10.1203/PDR.0b013e3181ac4a30; PMid:19617811

6. Dehnhard M, Claus R, Munz O et al. 2000. Course of epidermal growth factor (EGF) and insulinlike growth factor I (IGFI) in mammary secretions of the goat during endpregnancy and early lactation. Journal of Veterinary Medicine. 47: 533—540. https://doi.org/10.1046/j.1439-0442.2000.00315.x; PMid:11244861

7. Golin R, Amato M, Favaro F, Faggian D. 2007. Cytokines in human colostrum and neonatal jaundice. Pediatr Res. 62: 191—194. https://doi.org/10.1203/PDR.0b013e31809871c9; PMid:17597660

8. Apaydin K, Ermis B, Arasli M et al. 2012. Cytokines in human milk and lateonset breast milk jaundice. Pediatrics International. 54: 801—805. https://doi.org/10.1111/j.1442-200X.2012.03680.x; PMid:22672115

9. Jorgensen MN, Ott P, Juul A et al. 2003. Does breast feeding influence liver biochemistry? J Pediatr Gastroenterol Nutr. 37: 559—565. https://doi.org/10.1097/00005176-200311000-00010; PMid:14581797

10. Hargreaves T. 1973. Effect of fatty acids on bilirubin conjugation. Arch Dis Child. 48: 446-450. https://doi.org/10.1136/adc.48.12.984-b; https://doi.org/10.1136/adc.48.6.446; PMid:4740270 PMCid:PMC1648434

11. Mizejewski GJ. 2003. Levels of alphafetoprotein during pregnancy and early infancy in normal and disease states. Obstet Gynecol Surv. 56: 804—826. https://doi.org/10.1097/01.OGX.0000099770.97668.18; PMid:14668662

12. Pouliot Y, Gauthier S. 2006. Milk growth factors as health products: Some technological aspects. International Dairy Journal. 16: 1415—1420. https://doi.org/10.1016/j.idairyj.2006.06.006

13. Manganaro R, Marseglai L, Mami C et al. 2008. Serum alphafetoprotein (AFP) levels in breastfed infants with prolonged indirect hyperbilirubinemia. Early Human Development. 84: 487—490. https://doi.org/10.1016/j.earlhumdev.2008.01.005; PMid:18276085

14. Xiao L, Zhang X, Wang X et al. 2013. Changes in epidermal growth factor concentrations in neonates with lateonset breast milk jaundice after stopping breast feeding. Chin J Contemp Pediatr. 15: 1079—1081.