• Enterosorption in treatment of high risk pregnant women with early pregnancy toxaemia

Enterosorption in treatment of high risk pregnant women with early pregnancy toxaemia

PERINATOLOGY AND PEDIATRIC. UKRAINE. 2018.3(75):40-44; doi 10.15574/PP.2018.75.40

Ogorodnyk A. O., Limanskaya А. Yu., Tarnavska A. O., Davydova Iu. V.
SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine, Kyiv

Objective: to evaluate the efficacy of Atoxil gel in high risk pregnant women with mild early pregnancy toxaemia.

Materials and methods. The efficacy of the drug Atoxil gel (manufactured by TOV «Orisil_Farm») in pregnant women with mild early pregnancy toxaemia was studied. The study group included 87 pregnant women with cardiovascular pathology. According to the entry criteria, pregnants with extragenital pathology, which may cause nausea and vomiting (gastrointestinal pathology, severe heart failure, infectious diseases, etc.), were excluded from the study. The quality of life was studied using the Gastrointestinal Symptom Rating Scale (GSRS) questionnaire. All pregnant women were administered the drug Atoxyl gel in sticks (1 stick pack of 20 g of the gel 3 times a day) for 10-14 days.

Results. The high sorption capacity of Atoxil against microorganisms and bacterial toxins, the possibility of using moderate therapeutic doses due to the increased active surface area, the increased binding to bacteria and their toxins contribute to a rapid therapeutic effect. The selectivity of sorption action of the drug against pathological proteins and adhesive proteins on the membranous surface of the pathogenic microorganisms, due to the sorbent structure and based on the electrochemical interaction of particles, provides an additional benefit of its administration. No risk of loss of nutrients (amino acids, vitamins and minerals), obtained by the body from food, makes this sorbent a prime choice drug in the clinical management of pregnant women. The use of Atoxyl gel does not increase the constipation, which is very important during pregnancy.

Conclusions. The non-invasive pattern of Atoxil use, oral administration, ease of administration, high efficacy in early pregnancy toxaemia — all these factors contribute to improving the life quality and general well-being of pregnant women. The high safety profile allows recommending the aforementioned drug for the treatment of mild early pregnancy toxaemia.

Key words: pregnancy, early pregnancy toxaemia, intestinal sorbent, Atoxil.

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Article received: Jun 24, 2018. Accepted for publication: Sep 04, 2018.