• Enterosorption in treatment of high risk pregnant women with early pregnancy toxaemia

Enterosorption in treatment of high risk pregnant women with early pregnancy toxaemia

PERINATOLOGY AND PEDIATRIC. UKRAINE. 2018.3(75):40-44; doi 10.15574/PP.2018.75.40

Ogorodnyk A. O., Limanskaya А. Yu., Tarnavska A. O., Davydova Iu. V.
SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine, Kyiv

Objective: to evaluate the efficacy of Atoxil gel in high risk pregnant women with mild early pregnancy toxaemia.

Materials and methods. The efficacy of the drug Atoxil gel (manufactured by TOV «Orisil_Farm») in pregnant women with mild early pregnancy toxaemia was studied. The study group included 87 pregnant women with cardiovascular pathology. According to the entry criteria, pregnants with extragenital pathology, which may cause nausea and vomiting (gastrointestinal pathology, severe heart failure, infectious diseases, etc.), were excluded from the study. The quality of life was studied using the Gastrointestinal Symptom Rating Scale (GSRS) questionnaire. All pregnant women were administered the drug Atoxyl gel in sticks (1 stick pack of 20 g of the gel 3 times a day) for 10-14 days.

Results. The high sorption capacity of Atoxil against microorganisms and bacterial toxins, the possibility of using moderate therapeutic doses due to the increased active surface area, the increased binding to bacteria and their toxins contribute to a rapid therapeutic effect. The selectivity of sorption action of the drug against pathological proteins and adhesive proteins on the membranous surface of the pathogenic microorganisms, due to the sorbent structure and based on the electrochemical interaction of particles, provides an additional benefit of its administration. No risk of loss of nutrients (amino acids, vitamins and minerals), obtained by the body from food, makes this sorbent a prime choice drug in the clinical management of pregnant women. The use of Atoxyl gel does not increase the constipation, which is very important during pregnancy.

Conclusions. The non-invasive pattern of Atoxil use, oral administration, ease of administration, high efficacy in early pregnancy toxaemia — all these factors contribute to improving the life quality and general well-being of pregnant women. The high safety profile allows recommending the aforementioned drug for the treatment of mild early pregnancy toxaemia.

Key words: pregnancy, early pregnancy toxaemia, intestinal sorbent, Atoxil.


1. Davydova Iu, Voloshina T, Limanskaya A, Tuday V, Dvulit M, Baranova V. (2014). Morning sickness of pregnancy: evaluation of risks and tactics. Health of woman. 6: 62—66.

2. Davydova IuV, Limanskaya AYu, Butenko LP, Ogorodnik AA. (2016). Antiemetic therapy of early toxicity in pregnant women with congenital heart disease. Perinatologiya i pediatriya. 3(67): 35—37. https://doi.org/10.15574/PP.2016.66.43; https://doi.org/10.15574/PP.2016.67.35

3. Medychna khimiia i klinichne zastosuvannia dioksydu kremniiu. (2003). Za red. akad. A.A. Chuiko. Kyiv: Naukova Knyha:175—178.

4. American College of Obstetrics and Gynecology, authors. (2004). Practice Bulletin: nausea and vomiting of pregnancy. Obstet Gynecol. 103: 803—814. https://doi.org/10.1097/00006250-200404000-00045; PMid:15051578

5. Furneaux EC, Langley3Evans AJ, Langley3Evans SC. (2001). Nausea and vomiting'of pregnancy: endocrine basis and contribution to pregnancy outcome. Obstet. Gynecol. Surv. 56: 775—782. https://doi.org/10.1097/00006254-200112000-00004; PMid:11753180

6. Kocak I, Akcan Y, Ustun C. (2009). Helicobacter pylon seropositivity in patients with hyperemesis gravidarum. Int. J. Gynaecol. Obstet. 66: 251—254. https://doi.org/10.1016/S0020-7292(99)00091-0

7. Koch KL, Stern RM, Vascy M. (2010). Gastric dysrhythmias and nausea of pregnancy. Dig Dis Sci. 35: 961—968. https://doi.org/10.1007/BF01537244

8. Sonkusare S. (2008). Hyperemesis gravidarum: a review. Med Journal Malaysia. 63: 272—276. PMid:19248711

9. Tan PC, Khine PP, Vallikkannu N, Zawiah SZ. (2010). Promethazine compared with metoclopramide for hyperemesis gravidarum: a randomized controlled trial. Obstet Gynecol. 115: 975—981. https://doi.org/10.1097/AOG.0b013e3181d99290; PMid:20410771

10. Veenendaal MV, van Abeelen AF, Painter RC et al. (2011). Consequences of hyperemesis gravidarum for offspring: a systematic review and metaanalysis. BJOG. 118: 1302—1313. https://doi.org/10.1111/j.1471-0528.2011.03023.x; PMid:21749625

11. Еl3Younis CM, Abulafia O, Sh'erer DM. (2008). Rapid marked' response of severe hyperemesis gravidarum to oral erythromycin. Am. J. Perinatol. 15: 533—534.

Article received: Jun 24, 2018. Accepted for publication: Sep 04, 2018.