• Enterosorption as a Method of Chronic Kidney Disease Treatment in Pregnant Women

Enterosorption as a Method of Chronic Kidney Disease Treatment in Pregnant Women

PERINATOLOGY AND PEDIATRIC. UKRAINE. 2018.4(76):38-43; doi 10.15574/PP.2018.76.38

Limanskaya A. Yu., Tarnavska A. O., Davydova Iu. V.SI
«Institute of Pediatrics, Obstetrics and Gynecology named after Academician O.M. Lukyanova, National Academy of Medical Sciences of Ukraine», Kyiv

Aim: to investigate the efficacy of treatment for pregnant women with chronic II–III stage kidney disease due to glomerulonephritis.

Patients and methods. The study involved pregnant women who received treatment at 16–28 weeks of gestation during the first hospitalization to the unit. Women with chronic kidney disease were divided into two groups. The first group included 11 pregnant women who received traditional therapy (corticosteroids, potassium-retaining diuretics and cytostatics, if necessary, antihypertensives, antibiotics, drugs that improve renal microcirculation, etc.). The second group included 16 pregnant women who received traditional treatment along with maintenance therapy with the drug Atoxil, 1 vial (10 g of the formulation in the form of aqueous suspension) during the day in intervals between meals distributed evenly for 3 times. The duration of the sorbent course was 14–16 days.

Results and conclusions. The increase in the number of people with kidney disease accompanied by nitrogen metabolism disorders, as well as significant economic cost of treatment, leads to the search for additional available effective therapies. Among such methods is enteral enterosorption. Reducing endotoxin burden on organs and systems in combination with etiopathogenetic therapy can significantly improve condition of pregnant women, reduce manifestations of intoxication and improve the quality of life of women. Therefore, chronic kidney disease in the stage of azotemia is an indication for efferent therapy in the form of enteral enterosorption with the drug Atoxil (produced by Orisil-Pharm). Non-invasive nature of detoxification and proven efficacy make it possible to recommend Atoxil for the treatment of pregnant women.

Key words: pregnant, enterosorbtion, chronic kidney disease, Atoxil.

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Article received: Sep 11, 2018. Accepted for publication: Dec 03, 2018.