• Endothelial function status in chldren with juvenil rheumatoid arthritis. 
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Endothelial function status in chldren with juvenil rheumatoid arthritis. 

SOVREMENNAYA PEDIATRIYA.2014.2(58):70-75; doi 10.15574/SP.2014.58.70 
 

Endothelial function status in chldren with juvenil rheumatoid arthritis. 
 

Beregnoi V., Romankevych I.

P.L.Shupik National Medical Academy of Postgraduate Education, Kiev, Ukraine 

Cardio-vascular pathology is the main cause of death in patients with rheumatoid arthritis. Endothelial dysfunction is the first stage of vascular damage. The aim of our research was to complex study endothelial function and influence factors on endothelium. 
 

Materials and methods: 37 patients were examined during 2011–2013 years, 18 boys and 19 girls. The average age of the group was 11.87 ± 0.56 years. Mean disease duration was 3.45 ± 0.6 years. Flow-mediated dilatation (FMD) of the brachial artery, reactive hyperemia (RH), were used. 
 

Results: in children with JRA decries of FMD, RH, KV vs control group. In 10 (27%) children with JRA artery spasm was observed. The main factors which influence on endothelial function were disease activity and inflammatory markers, arterial blood pressure and it daily character and systemic glucocorticosteroid and folic acid used. 
 

Key words: juvenile rheumatoid arthritis, endothelial function. 
 

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