• Endothelial function and vasoactive factors in adolescents with arterial hypertension and hyperuricemia
To content

Endothelial function and vasoactive factors in adolescents with arterial hypertension and hyperuricemia

SOVREMENNAYA PEDIATRIYA. 2014. 5(61):53-58; doi 10.15574/SP.2014.61.53

Endothelial function and vasoactive factors in adolescents with arterial hypertension and hyperuricemia

Bessonova I. N. 
ST “Institute of Children and Adolescents Health Care of NAMS of Ukraine”, Kharkiv, Ukraine

To study the peculiarities of endothelial function in adolescents with arterial hypertension based on the values of their body weight and the presence of hyperuricemia, to determine the relationship between the level of stable metabolites of nitric oxide and endothelin blood-I with the duration and characteristics of hypertension, as well as markers of endothelial dysfunction kidney.

Material and methods: 115 young men with arterial hypertension aged 14-18 years, of whom 30 (26.1%) had normal weight, 26 (22.6%) – the excess, 59 (51.3%) – оbesity. The level of serum uric acid blood programming nitric oxide, endothelin-I levels and blood Я2-microglobulin, albuminuria. Endothelial function was assessed in tests with endothelium-dependent vasodilation and endothelium procedure Celermajer et al. (1992).

Results. The majority of adolescents with hypertension showed signs of endothelial dysfunction, especially pronounced when combined with obesity hyperuricemia. Changes of the level of the amount of nitric oxide metabolites and endothelin-I at different duration of hypertension and their relation with markers of endothelial dysfunction of kidneys.

Conclusions. The presence of hyperuricemia in adolescents with arterial hypertension had no effect on the frequency of violations of vasodilation, but significantly aggravated her obese persons. Level amounts of nitrite-nitrate increased and endothelin-I went down in the early stages of arterial hypertension. When stabilization of arterial hypertension observed opposite changes in endothelial vasoactive factors. Amount of nitrite-nitrate levels associated with Я-2 microglobulin blood, and endothelin-I-with values of albuminuria.

Key words: arterial hypertension, teens, hyperuricemia, endothelial function, nitric oxide, endothelin

1. Бобров ВА, Фирсова ИГ. 2010. Метаболизм оксида азота и эндотелиальная дисфункция у больных с эссенциальной артериальной гипертензией с признаками ремоделирования левого желудочка. Укр кардіол журн 3: 58–63.

2. Дудчак АП. 2008. Оксид азота как маркер риска формирования артериальной гипертензии у детей. Здоровье ребенка 4: 59–62.

3. Лапшина ЛА и др. 2009. Значение определения нитритов-нитратов как маркеров дисфункции эндотелия при сердечно-сосудистой патологии. Укр мед часоп 6: 49–53.

4. Коваль СН, Божко ВВ, Мысничеко ОВ. 2009. Нарушения пуринового обмена и артериальная гипертензия. Укр ревм журн 4: 75–80.

5. Маркелова ЕИ, Елисеев МС, Барскова ВГ. 2012. Артериальная гипертензия у больных подагрой: основы патогенеза, клиническое значение, диагностика. Совр ревматол 4: 23–30.

6. Пузанова ОГ, Таран АИ. 2009. Гиперурикемия и кардиоваскулярный континуум. Внутренняя медицина 3: 9–17.

7. Ребров АП, Куклина АЛ. 2012. Взаимосвязи функционального состояния почек и эндотелиальной дисфункции у больных артериальной гипертензией. Клин нефрол 5–6: 19–23.

8. Люсов ВА и др. 2011. Уровень оксида азота в сыворотке периферической крови больных с различной тяжестью артериальной гипертензии. Кардиология 12: 23–28.

9. Alvarez-Lario B, Macarron-Vicente J. 2011. Is the anything good in uric acid? JM 12: 1015–1024.

10. Nashar K, Fried LF. 2012. Hyperuricemia and the progression of chronic kidney disease: is uric acid a marker or an independent risk factor? Adv. Chronic. Kidney Dis 19(6): 386–391. http://dx.doi.org/10.1053/j.ackd.2012.05.004

11. Levi AS et al. 2009. Nitric oxide and coronary vascular endothelium adaptation in hypertension Vascul Health and Risk Managem 5: 1075–1087.

12. Raij L. 2008. Nitric oxide and cardiovascular and renal effects Osteoarthritis. Cartilage 16: 21–26. http://dx.doi.org/10.1016/S1063-4584(08)60009-6

13. Kawai Т et al. 2012. Serum uric acid is an independent risk factor for cardiovascular disease and mortality in hypertensive patients. Hypertens Res 35(11): 1087–1092. http://dx.doi.org/10.1002/art.24164

14. Chen J et al. 2009. Serum Uric Acid Level as an Independent Risk Factor for All-Cause, Cardiovascular, and Ischemic Stroke Mortality: A Chinese Cohort Study. Arthritis Care & Research 61(2): 225–232. http://dx.doi.org/10.1002/art.24164

15. Kim IY et al. 2014. The Role of Uric Acid in Kidney Fibrosis: Experimental Evidences for the Causal Relationship. Biomed Res Int.

16. Johnson RJ et al. 2013.Uric acid and chronic kidney disease: which is chasing which? Nephrol Dial Transplant 28(9): 2221–2228. http://dx.doi.org/10.1093/ndt/gft029

17. Zoccali C, Mario R, Mallamaci F et al. 2006. Uric acid and endothelial dysfunction in essential hypertension. J Am Soc Nephrol 17: 1466–1471.