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Endothelial function and vasoactive factors in adolescents with arterial hypertension and hyperuricemia

SOVREMENNAYA PEDIATRIYA. 2014. 5(61):53-58; doi 10.15574/SP.2014.61.53

Endothelial function and vasoactive factors in adolescents with arterial hypertension and hyperuricemia

Bessonova I. N. 
ST “Institute of Children and Adolescents Health Care of NAMS of Ukraine”, Kharkiv, Ukraine

To study the peculiarities of endothelial function in adolescents with arterial hypertension based on the values of their body weight and the presence of hyperuricemia, to determine the relationship between the level of stable metabolites of nitric oxide and endothelin blood-I with the duration and characteristics of hypertension, as well as markers of endothelial dysfunction kidney.

Material and methods: 115 young men with arterial hypertension aged 14-18 years, of whom 30 (26.1%) had normal weight, 26 (22.6%) – the excess, 59 (51.3%) – оbesity. The level of serum uric acid blood programming nitric oxide, endothelin-I levels and blood Я2-microglobulin, albuminuria. Endothelial function was assessed in tests with endothelium-dependent vasodilation and endothelium procedure Celermajer et al. (1992).

Results. The majority of adolescents with hypertension showed signs of endothelial dysfunction, especially pronounced when combined with obesity hyperuricemia. Changes of the level of the amount of nitric oxide metabolites and endothelin-I at different duration of hypertension and their relation with markers of endothelial dysfunction of kidneys.

Conclusions. The presence of hyperuricemia in adolescents with arterial hypertension had no effect on the frequency of violations of vasodilation, but significantly aggravated her obese persons. Level amounts of nitrite-nitrate increased and endothelin-I went down in the early stages of arterial hypertension. When stabilization of arterial hypertension observed opposite changes in endothelial vasoactive factors. Amount of nitrite-nitrate levels associated with Я-2 microglobulin blood, and endothelin-I-with values of albuminuria.

Key words: arterial hypertension, teens, hyperuricemia, endothelial function, nitric oxide, endothelin

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