• Endothelial dysfunction and functional status of intestinal mucosal barrier in asphyxiated low birth weight infants 

Endothelial dysfunction and functional status of intestinal mucosal barrier in asphyxiated low birth weight infants 

SOVREMENNAYA PEDIATRIYA.2016.2(74):56-61; doi 10.15574/SP.2016.74.56 

Endothelial dysfunction and functional status of intestinal mucosal barrier in asphyxiated low birth weight infants 

Huseynova S. A., Panakhova N. F., Orujova P. A., Hajiyeva N. N., Adilova A. I.

Azerbaijan Medical University, Neonatology Department, Baku, Azerbaijan 

Aim of study. The main prpose of present study was to determine the effect of endothelial dysfunction to the levels of markers of functional state of digestive system in infants with perinatal hypoxia. 

Materials and methods. The neuronal dysfunction was detected basing on the levels of NSE and NR2 antibodies. The functional state of gastrointestinal tract was estimated by IFABP, sLFABP, MUC-2, ITF, LBP. As the markers of endothelial dysfunction it was detected endotelin-1 and NO. The concentrations of markers were determined in peripheral blood of 66 preterm newborns exposure intrauterine hypoxia with 32–36 weeks of gestational age, which were classified as asphyxiated (1st group, n=30), non asphyxiated (2nd group, n=36) infants. Control group consisted of 22 healthy preterm babies. 

Results. It was not detected significant difference of NSE and NR2 antibodies levels between 1st and 2nd groups. The endothelin-1 concentrations significantly decreased in asphyxiated group in the background of high NO levels. The elevated level of IFABP in asphyxiated infants associated with compensative increasing of ITF and low anti endotoxine immunity. 

Conclusion. Endothelial dysfunction is one of the main factor resulting in hypoxic-ischemic injury of gastrointestinal tract in asphyxiated low birth weight infants. 

Key words: preterm birth, asphyxia, intestinal barrier, endothelial dysfunction. 

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