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Endometrial hyperplasia (Clinical lecture)

HEALTH OF WOMAN. 2016.5(111):10–18; doi 10.15574/HW.2016.111.10

Endometrial hyperplasia (Clinical lecture)

Vovk I. B., Gorban N. Е., Borysiuk O. Ju.

SI «Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine», Kiev

In clinical lecture presents modern views of endometrial hyperplasia in terms of practitioner gynecologist. The problems of classification, pathogenetic mechanisms of development of endometrial hyperplasia. Particular attention is paid to modern approaches to diagnosis and treatment of endometrial hyperplasia.

Key words: hyperplasia, endometrium, classification, endometrial hyperplasia, endometrial intraepithelial neoplasia, hormonal therapy.


1. Lacey JV, Sherman ME, Rush BB et al. 2010. Absolute risk of endometrial carcinoma during 20-year follow-up among women with endometrial hyperplasia. J. Clin. Oncol. 28(5):788-92. http://dx.doi.org/10.1200/JCO.2009.24.1315; PMid:20065186 PMCid:PMC2834395

2. Giuntoli RL, Gerardi MA, Yemelyanova AV et al. 2012. Stage Inoninvasive andminimallyinvasive uterine serous carcinoma: comprehensive staging associated with improved survival. Int. J. Gynecol. Cancer. 22(2):273-9. http://dx.doi.org/10.1097/IGC.0b013e318238df4d; PMid:22146771

3. Sheshukova NA, Makarov IO, Ovsyannikov TV. 2011. Endometrial hyperplastic processes: especially proliferative activity when combined with chronic endometritis. Obstetrics, Gynecology and Reproduction. 5(3):10-5.

4. Acmaz G, Aksoy H, Albayrak E et al. 2014. Evaluation of endometrial precancerous lesions in postmenopausal obese women-a high risk group? Asian. Pac. J. Cancer Prev. 15(1):195-8. http://dx.doi.org/10.7314/APJCP.2014.15.1.195; PMid:24528026

5. Martirosyan KA, Karachentsova IV, Politova AP et al. 2011. Comprehensive treatment of endometrial hyperplasia in patients with pre-period and menopause. Journal of Russian State Medical University. Specialist. 2:109-12. Current Issues in Obstetrics and Gynecology: V materials int'l conference of young scientists, Moscow, May 20, 2011.

6. Munro MG, Dickersin K, Clark MA et al. 2011. The Surgical Treatments Outcomes Project for Dysfunctional Uterine Bleeding: summary of an Agency for Health Research and Quality-sponsored randomized trial of endometrial ablation versus hysterectomy for women with heavy menstrual bleeding. Menopause 18(4):445-52. http://dx.doi.org/10.1097/gme.0b013e31820786f1; PMid:21701431

7. Trimble CL, Method M, Leitao M et al. 2012. Management of endometrial precancers. Obstet. Gynecol. 120(5):1160-75. PMid:23090535 PMCid:PMC3800154

8. Pennant S, Manek S, Kehoe S. 2008. Endometrial atypical hyperplasia and subsequent diagnosis of endometrial cancer: a retrospective audit and literature review. J. Obstet. Gynaecol. 28(6):632-3. http://dx.doi.org/10.1080/01443610802355817

9. Daya D. 2014. Endometrial hyperplasia and carcinoma with superimposed secretory changes: a double whammy. Int. J. Gynecol. Pathol. 33(2):105-6. http://dx.doi.org/10.1097/pgp.0000000000000115

10. Gynecology. A Guide for Physicians. Eds. by VN Serov, EF Kira. Moscow. 2008:840.

11. Zheleznov BI. 1993. Tumors of the female genital tract. Pathologic diagnosis of human tumors. Guide. Eds. By Krajewski, AV Smolyannikova, DS Sarkisov. M. Health.

12. Kuznetsova IV. 2009. Endometrial hyperplasia. Moscow:48.

13. Poulsen GE, Taylor KU, Sobin LG. 1981. International histological classification of tumors number 13. The histological classification of tumors of the female genital tract. WHO, Geneva.

14. Khmelnytsky NM, Neustadt EL, Halimdzhanov ZK. 2006. Difficulties and error diagnostics of atypical endometrial hyperplasia. Arch. US Pat. 6:39-42.

15. Khmelnitsky DC. 2000. Cytological and histological diagnosis of cervical and uterine. DC body diseases Khmelnitsky. SPb, SOTIS:333.

16. Kurman RJ, Norris HJ. 1995. Endometrial hyperplasia and related cellular changes. Blaustein’s pathology of the female genital tract. Ed. by RJ Kurman – 5th ed. New York:411-37.

17. Мutter GL, Zaino RJ, Baak JP et al. 2007. Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia. International Journal of Gynecological Pathology 26(2):103-14. http://dx.doi.org/10.1097/PGP.0b013e31802e4696; PMid:17413975

18. Orbo A, Baak JP, Kleivan I et al. 2000. Computerised morphometrical analysis in endometrial hyperplasia for the prediction of cancer development. A long-term retrospective study from northern Norway. Journal of Clinical Pathology 53(9):697-703. http://dx.doi.org/10.1136/jcp.53.9.697; PMid:11041060 PMCid:PMC1731244

19. Silverberd SG, Kurman RJ, Nogales F. 2003. WHO Classifications of Tumors. Pathology and Genetics. Tumors of the Brest and female genital organs. Eds by FA Tavassali, P Deviler. Lyon:33-7.

20. Skov BG, Broholm Н, Engel U et al. 1997. Comparison of the reproducibility of the WHO classifications of 1975 and 1994 of endometrial hyperplasia. Int. J. Gynecol. Pathol. 16(1):33-37. http://dx.doi.org/10.1097/00004347-199701000-00006; PMid:8986530

21. Zaino RJ, Kanderer J, Trimble CL. 2006. Reproducibility of the Diagnosis of Atypical Endometrial Hyperplasia. Cancer. 106:804-11. http://dx.doi.org/10.1002/cncr.21649; PMid:16400640

22. Zaporozhan VN, Tatarchuk TF, Dubinin VG, Kosei NV. 2012. Current diagnosis and treatment of endometrial hyperplastic processes. Reproductive endokrinologiya 1(3):5-12.

23. Tatarchuk TF, Kalugin LA. 2012. On the question of the treatment of endometrial hyperplasia. Reproductive Endocrinology 2(4):88-92.

24. Tatarchuk TF, Kalugin LV, Tutchenko TN. 2015. Endometrial hyperplastic processes: what's new? Reproductive Endocrinology 5(25):7-13. http://dx.doi.org/10.18370/2309-4117.2015.25.7-13