- The effectiveness of different forms of micronized progesterone in the treatment of abortion
The effectiveness of different forms of micronized progesterone in the treatment of abortion
HEALTH OF WOMAN. 2017.5(121):74–77; doi 10.15574/HW.2017.121.74
Pyrohova V., Kozlovskyy І., Veresnyuk N., Malachynska M.
Lviv national medical University named Danylo Galitsky
The research for the purpose of efficiency compared application of vaginal and sublingual form of micronized progesterone in the treatment of a threatened miscarriage of І and II trimesters of pregnancy.
Under the supervision were 58 pregnant women who were found during the test retrohorial hematoma. Depending on the route of administration of micronized progesterone patients were divided into 2 groups.
The first group included 28 women who were prescribed according to the instructions vaginal tablets Luteina.
The second group consisted of 30 patients who used sublingually Luteina.
Monitoring the effectiveness of treatment carried out by clinical and laboratory course of the disease based on the dynamic changes of patients complaints, evaluations of ultrasound data in dynamics.
The results showed that the effectiveness of treatment when using sublingual or vaginal routes of administration Luteina did not differ significantly, the use of micronized progesterone possible to maintain pregnancy in 79.3% of patients with retrohorial hematomas.
Unfavorable factors for the development of pregnancy is central and retrohorial large hematoma.
Key words: threatened miscarriage, retrohorial hematomas, micronized progesterone, treatment.
1. Dobrohotova YuE, Dzhobava EM, Ozerova RI. 2010. Nerazvivayuschayasya beremennost. M, GEOTAR-Media:144.
2. Veropotvelyan NP. 2016. K voprosu ob effektivnosti primeneniya progesteronov pri povtornyih rannih reproduktivnyih poteryah. Reproduktivna endokrinologiya 5(31):22–27.
4. Schindler AE et al. 2015. European Progestin Club Guidelines for prevention and treatment of threatened or recurrent (habitual) miscarriage with progestogens. Gynecol Endocrinol. 31:447–449. https://doi.org/10.3109/09513590.2015.1017459; PMid:25976550
5. Coomarasamy A et al. 2015. A Randomized Trial of Progesterone in Women with Recurrent Miscarriages. N Engl J Med. 373:2141–2148. https://doi.org/10.1056/NEJMoa1504927; PMid:26605928
6. Johns J, Hyett J, Jauniaux E. 2003. Obstetric outcome after threatened miscarriage with and without a hematoma on ultrasound. Obstet Gynecol. 102(3):483–487. https://doi.org/10.1016/S0029-7844(03)00580-5; https://doi.org/10.1097/00006250-200309000-00010; PMid:12962928
7. Schauberger CW, Mathiason MA, Rooney BL. 2005. Ultrasound assessment of first-trimester bleeding. Obstet. Gynecol. 105(2):333–338. https://doi.org/10.1097/01.AOG.0000151105.53557.27; PMid:15684161