• The effectiveness of antibacterial therapy in planning pregnancy in woman with risk factors of intrauterine infection
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The effectiveness of antibacterial therapy in planning pregnancy in woman with risk factors of intrauterine infection

HEALTH OF WOMAN. 2017.10(126):70–74; doi 10.15574/HW.2017.126.70

Heryak S. M., Petrenko N. V., Dobryansky V. Yu., Kutsenko V. V., Korda I. V., Bahnij N. I., Stelmakh O. Ye.
SHEI «Ternopil State Medical University named after I.Ya. Gorbachevsky Ministry of Health of Ukraine»
TRС «Ternopil Regional Perinatal Center «Mother and Child»

Inflammatory diseases of the pelvic organs, including chlamydial infection, significantly impair the quality of women’ life, reduce the possibility of the development of pregnancy as a result of tubal-peritoneal damage by the infection, do adversely affect on duration of pregnancy, postpartum period and the newborn.
The objective: to determine the efficacy of the use of the modern antibiotic fluoroquinolone III generation Levoksimed (World Medicine) to improve the quality of reproductive health in women with chlamydial infection in the program of pregravid preparation.
Patients and methods. The study included 58 women (study group) who, when contacting a women's consultation about pregnancy planning, identified and confirmed a chlamydial infection. The control group included 18 practically healthy women.
Results. After the treatment we offered, all the patients noted improvement in overall health, 46 (80%) decreased the number of complaints of chronic pelvic pain, 53 (91%) discontinued pathologic discharge from the genital tract. Intolerance and side effects of this treatment in no case is not documented. Only one patient (1.7%) after 5 days of treatment was diagnosed with mild intestinal dysbiosis. Based on the results of the repeated PCR-examination, the examined women of the genetic material C. trachomatis were not detected. After the treatment, 28 (48%) of the patients became pregnant independently. It should be noted that in the women treated by us, the pregnancy proceeded without deviations and complications. They had live full-term infants with no signs of intrauterine infection.
Conclusions. Levoximed makes a high bactericidal activity, has good tolerability and safety, that is possible to use it as a drug for choice in women with risk factors of intrauterine infection, planning pregnancy.
Key words: chlamydial infection, antibacterial therapy, quality of life, pregnancy, Levoximed.


1. Bouquier J, Fauconnier A, Fraser W, Dumont A, Huchon C. 2012. Diagnosis of pelvic inflammatory disease: which clinical and paraclinical criteria? Role of imaging and laparoscopy. J Gynecol Obstet Biol Reprod (Paris). 41(8):835–49. https://doi.org/10.1016/j.jgyn.2012.09.016; PMid:23140620

2. Cluver C, Novikova N, Eriksson DO, Bengtsson K, Lingman GK. 2017, Sep 22. Interventions for treating genital Chlamydia trachomatis infection in pregnancy. Cochrane Database Syst Rev. 9:CD010485. https://doi.org/10.1002/14651858.CD010485.pub2

3. Lamoth F, Schrenzel J, Greub G. 2014. Diagnostic approach of intracellular bacteria and fastidious microorganisms. Rev Med Suisse. 10(450):2130–2136. PMid:25549373

4. Lanjouw E, Ouburg S, de Vries HJ, Stary A, Radcliffe K, Unemo M. 2015. European guideline for the management of Сhlamidia trachomatis infections. – http://journals.sagepub.com/doi/abs/10.1177/0956462415618837

5. Low N, Redmond S, Uusküla A, van Bergen J, Ward H, Andersen B, Götz H. 2016, Sep 13. Screening for genital chlamydia infection. Cochrane Database Syst Rev. 9:CD010866. https://doi.org/10.1002/14651858.CD010866.pub2

6. Nsonwu-Anyanwu AC, Charles-Davies MA, Taiwo VO, Li B, Oni AA, Bello FA. 2015. Female reproductive hormones and biomarkers of oxidative stress in genital Chlamydia infection in tubal factor infertility. J Reprod Infertil. 16(2):82–89. PMid:25927024 PMCid:PMC4386090

7. O’Connell CM, Ferone ME. 2016. Chlamydia trachomatis Genital Infections. Microb Cell. 3(9):90–403. https://doi.org/10.15698/mic2016.09.525

8. Price MJ, Ades AE, Welton NJ, Macleod J, Turner K, Simms I et al. 2012. How much tubal factor infertility is caused by Chlamydia? Estimates based on serological evidence corrected for sensitivity and specificity. Sex Transm Dis. 39(8):608–613. https://doi.org/10.1097/OLQ.0b013e3182572475; PMid:22801343

9. Rawre J, Juyal D, Dhawan B. 2017. Molecular typing of Chlamydia trachomatis: An overview. Indian J Med Microbiol. 35(1):17–26. https://doi.org/10.4103/ijmm.IJMM_16_341; PMid:28303813

10. Samarawickrema NA, Tabrizi SN, Young E, Gunawardena P, Garland SM. 2015. Prevalence of Trichomonas vaginalis, Chlamydia trachomatis, Neisseria gonorrhoeae and human papillomavirus in a sexual health clinic setting in urban Sri Lanka. Int J STD AIDS. 26(10):733–739. https://doi.org/10.1177/0956462414552813; PMid:25258396

11. Satterwhite CL, Torrone E, Meites E, Dunne EF, Mahajan R et al. 2013. Sexually transmitted infections among US women and men: prevalence and incidence estimates, 2008. Sex Transm Dis. 40(3):187–93. https://doi.org/10.1097/OLQ.0b013e318286bb53; PMid:23403598

12. Sexually Transmitted Diseases Treatment Guidelines. 2010.  https://www.cdc.gov/std/treatment/2010/default.htm