• Diagnostic of cognitive epileptiform disintegration with autism spectrum disorders in children of early ages 
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Diagnostic of cognitive epileptiform disintegration with autism spectrum disorders in children of early ages 

PERINATOLOGIYA I PEDIATRIYA. 2016.2(66):106-111; doi 10.15574/PP.2016.66.106 

Diagnostic of cognitive epileptiform disintegration with autism spectrum disorders in children of early ages 

Kirilova L. G., Tkachuk L. I., Miroshnikov O. O., Grabovenska I. O., Silaeva L. Y., Yuzva O. O.

SI «Institute of Pediatric, Obstetric and Gynecology of NAMS of Ukraine», Kyiv, Ukraine 

The article, based on the analysis of contemporary scientific literature, presented data on the etiology, pathogenesis, clinical features of cognitive epileptiform disintegration — a special version of autism spectrum disorders. The authors proposed a diagnostic algorithm of this condition in children on the basis of comprehensive clinical examination using brain MRI, EEG monitoring during activity and sleep. MRI identified specific changes in brain structure (macrocephaly, cerebellar hyperplasia, hypoplasia of the corpus callosum, hypoplasia of the thalamus, and others.) and specific epileptiform activity on EEG during activity and sleep (changes the focal character in the fronto-central and left temporal areas) in the absence or infrequent epileptic seizures, reduction of inhibitory neurotransmitter GABA in the blood 2–3 times. The developed methods enable timely diagnosis to diagnose cognitive epileptiform disintegration with autistic spectrum disorders and appoint pathogenetic treatment with drugs neurometabolic and neuroprotective action, and anticonvulsants. 

Key words: cognitive epileptiform disintegration, epileptic encefalopatia, autism spectrum disorders. 


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