• Definition of risk factors epithelium-mesenchymal transition in the urogenital tract of women mucosa in inflammatory conditions induced C. trachomatis, U.urealyticumand M. genitalium

Definition of risk factors epithelium-mesenchymal transition in the urogenital tract of women mucosa in inflammatory conditions induced C. trachomatis, U.urealyticumand M. genitalium

HEALTH OF WOMAN. 2016.6(112):144–148 

Definition of risk factors epithelium-mesenchymal transition in the urogenital tract of women mucosa in inflammatory conditions induced C. trachomatis, U.urealyticumand M. genitalium 

Anfilova M. R.

Vinnitsa national medical University M. I. Pirogov 

The objective: to establish a possible association between the type of agent, the type of infection, the duration of the inflammatory reaction in the mucosa of the urogenital tract, the content of intercellular adhesins on the one hand, and the detection rate increased content markers epithelium mesenchymal transition in the washings from the cervical canal during the period after the eradication of the pathogen in women infected with C. trachomatis, U. urealyticum and M. genitalium.

Patients and methods: 236 patients aged 19 to 39 years who underwent urogenital chlamydiosis /mycoplasmosis/ureaplasmosis, confirmed by PCR with the eradication of the pathogen. Depending on the type of source of the clinical course of infection (primary, secondary, latent) were distributed to the patient among the three groups. In turn, each group consisted of 3 subgroups on the type of pathogen. A survey of patients included: measurement of concentrations of intercellular adhesins ICAM-1 and VCAM serum markers of EMT (MMP-9, fibronectin) in cervical swabs, leukorrhea detection in cervical smears, determination of the intensity of the symptoms on the total score of symptoms. These procedures were carried out at 30±2, 60±5, 90±10, 120±10 and 180±10 days after standard antimicrobial therapies.

Results. During the study it was found that EMT mucous urogenitalnoogo risk factors tract of women who have had chlamydia, mycoplasmosis, ureaplasmosis is long (more than 30 days) maintenance of elevated concentrations of adhesins ICAM-1 and of VCAM, recurrent and latent during the initial infection. pathogen type does not affect the likelihood of developing EMT.

Conclusion. The probability of EMT in the urogenital tract of women who have had an infection caused by C. trachomatis, U. Urealyticum and M. genitalium, is dependent on the duration of the maintenance of elevated concentrations of intercellular adhesins in the serum and increases the risk of EMT 17.2–19.2%. Further studies are needed to determine the determinants of the persistence of the inflammatory mucosa of the urogenital tract reaction after elimination of antigen and methods of influencing them for the prevention of metaplasia and infertility.

Key words: chlamydiosis, mycoplasmosis, epithelium-mesenchymal transition, MMP-9, fibronectin, ICAM-1, VCAM, immunopathogenesis, vaginitis, cervicitis.


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