• Defining the role of polymorphism of genes of different classes in premature termination of pregnancy by various terms
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Defining the role of polymorphism of genes of different classes in premature termination of pregnancy by various terms

PERINATOLOGIYA I PEDIATRIYA. 2016.3(67):61-65; doi 10.15574/PP.2016.67.61 
 

Defining the role of polymorphism of genes of different classes in premature termination of pregnancy by various terms


Vorob'eva I. I., Skripchenko N. I., Tkachenko V. B., Rudakova N. V., Zhyvetskaya—Denisova A., Tolkach S. M.

SI «Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine», Kyiv


Purpouse — to define the reliable role of polymorphism of genes of different classes in premature termination of pregnancy by various terms.


Patients and methods. Under the supervision about the threat of interruption of pregnancy in obstetric hospitals SI «Institute of Pediatrics, Obstetrics, andGynecology of NAMS of Ukraine» in 2012–2014 were 153 women with the factors of increased risk of preterm birth and 86 women with reproductive function realized as a control.


Results. Distribution of the proportion of carriers of the protective alleles of the studied genes in women with miscarriage helped to establish protectionistpolymorphisms of the studied genes. In 68% of cases, the disruption of genes of thrombophilia and estrogen receptors was the cause of the primary violation and defective volkwagens desigualtat endometrium, which is a prerequisite of early and late obstetric complications. The presence of pathological polymorphisms in at least 5 genes from different classes or 2–3 genes trombly increase the risk of miscarriage in 32–54 times.


Conclusions. Women with noncarrying of pregnancy differ from women with the implementation of reproductive function of the number of mutant alleles ofgenes of different classes that are different contribution to the development of reproductive losses.


Key words: polymorphism of genes, premature termination of pregnancy.


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