• D-vitamin status and topical issues of its correction in patients with juvenile idiopathic arthritis

D-vitamin status and topical issues of its correction in patients with juvenile idiopathic arthritis

Perinatology and pediatric.Ukraine.2017.4(72):115-118; doi 10.15574/PP.2017.72.115

Omelchenko L. I.
SI «Institute of Paediatrics, Obstetrics and Gynecology of NAMS of Ukraine», Kyiv, Ukraine

Objective: to evaluate the vitamin D3 (Aquadetrim vitamin D3, aqueous solution, which contains 500 IU in 1 drop) effectiveness for correction of vitamin D deficiency or its insufficiency in children with juvenile idiopathic arthritis.
Material and methods. In total 56 children aged 3–15 years old with juvenile idiopathic arthritis and 10 apparently healthy children of the control group were examined. The 25(OH)D serum concentration was determined using commercial Vitamin D3-screening Kit (Switzerland) in accordance with the manufacturer's instructions.
Results. In all patients with juvenile idiopathic arthritis, the blood serum level of 25(OH)D (18±0.84 ng/ml) was found to be lower than in the children of control group (39.98±3.11 ng/ml). The lowest serum concentrations of 25(OH)D were in the patients with high activity of the disease. The administration of vitamin D3 (Aquadetrim vitamin D3) at doses of 2000-5000 IU per day for 1 to 2 months normalized the 25(OH)D serum levels and positively influenced the clinical course of the disease.
Conclusions. Children with juvenile idiopathic arthritis need to monitor 25(OH)D serum levels to assess their vitamin D status and select daily doses of vitamin D3 to correct deficiency or D-vitamin deficiency.
Key words: juvenile idiopathic arthritis, vitamin D status, correction.


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