- Cryptorchidism and varicocele: аnother look at the reasons for launching autoaggression
Cryptorchidism and varicocele: аnother look at the reasons for launching autoaggression
Paediatric Surgery.2017.3(56):75-83; doi 10.15574/PS.2017.56.75
Havrylyuk A. M., Chopyak V. V., Nakonechnyi Io. A., Nakonechnyi A. Io., Fraczek M., Kurpisz M.
Danylo Halytsky Lviv National Medical University, Ukraine
Institute of Human Genetics PAS, Poznan, Poland
Objective. To determine the role of oxidative stress and inflammation in the pathogenesis of subfertility/infertility and formation of autoimmunity in patients with cryptorchidism and varicocele.
Material and metods. Blood levels of MDA and IL-6 were measured in 48 boys with cryptorchidism and 20 healthy subjects. The spermal parameters (motility, morphology), blood levels of MDA and IL-6 were measured in 22 men with varicocele and 21 healthy subjects. The statistical processing was performed with using noparametrical methods and standart computer programs (Statistica Version 6, StatSoft, Inc.; SPSS Statistics 17.0, IBM).
Results. We showed that the level of МDA was significantly higher in blood of the cryptorchidism group compared with the control group (p=0.003). The blood serum concentration of IL-6 in the group with bilateral cryptorchidism as compared to the group with unilateral cryptorchidism was higher (p=0.001). We revealed that the levels of MDA, IL-6 and seminal parameters (low motility, sperm abnormalities) was higher in patients with varicocele compared to the control group (p<0.05; p=0.011). In our opinion, MDA is the most reliable and decisive biochemical marker displaying oxidative damage in undescended testes and varicocele, and may be triggered by an autoimmune response.
Conclusions. The level of МDA is higher in blood of groups with bilateral and unilateral cryptorchidism, as well as in blood and seminal plasma of patients with varicocele. The higher level of MDA correlates with low motility and higher level of sperm abnormalities in patients with varicocele. The tendency of increased IL-6 level in blood of groups with bilateral and unilateral cryptorchidism, also in blood and seminal plasma of patients with varicocele is a ponderable factor of oxidative stress and a trigger of automunity.
Key words: cryptorchidism, varicocele, MDA, IL-6, oxidative stress, autoimmunity, infertility.
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